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Risk assessment of substance use disorders based on the human leukocyte antigen (HLA)
Substance use disorders (SUDs) are common and costly conditions that are partially attributable to genetic factors. In light of immune system influences on neural and behavioral aspects of addiction, the present study evaluated the influence of genes involved in the human immune response, human leuk...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220069/ https://www.ncbi.nlm.nih.gov/pubmed/37237010 http://dx.doi.org/10.1038/s41598-023-35305-2 |
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author | James, Lisa M. Georgopoulos, Apostolos P. |
author_facet | James, Lisa M. Georgopoulos, Apostolos P. |
author_sort | James, Lisa M. |
collection | PubMed |
description | Substance use disorders (SUDs) are common and costly conditions that are partially attributable to genetic factors. In light of immune system influences on neural and behavioral aspects of addiction, the present study evaluated the influence of genes involved in the human immune response, human leukocyte antigen (HLA), on SUDs. We used an immunogenetic epidemiological approach to evaluate associations between the population frequencies of 127 HLA alleles and the population prevalences of six SUDs (alcohol, amphetamine, cannabis, cocaine, opioid, and “other” dependence) in 14 countries of Continental Western Europe to identify immunogenetic profiles of each SUD and evaluate their associations. The findings revealed two primary groupings of SUDs based on their immunogenetic profiles: one group comprised cannabis and cocaine, whereas the other group comprised alcohol, amphetamines, opioids, and “other” dependence. Since each individual possesses 12 HLA alleles, the population HLA-SUD scores were subsequently used to estimate individual risk for each SUD. Overall, the findings highlight similarities and differences in immunogenetic profiles of SUDs that may influence the prevalence and co-occurrence of problematic SUDs and may contribute to assessment of SUD risk of an individual on the basis of their HLA genetic makeup. |
format | Online Article Text |
id | pubmed-10220069 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-102200692023-05-28 Risk assessment of substance use disorders based on the human leukocyte antigen (HLA) James, Lisa M. Georgopoulos, Apostolos P. Sci Rep Article Substance use disorders (SUDs) are common and costly conditions that are partially attributable to genetic factors. In light of immune system influences on neural and behavioral aspects of addiction, the present study evaluated the influence of genes involved in the human immune response, human leukocyte antigen (HLA), on SUDs. We used an immunogenetic epidemiological approach to evaluate associations between the population frequencies of 127 HLA alleles and the population prevalences of six SUDs (alcohol, amphetamine, cannabis, cocaine, opioid, and “other” dependence) in 14 countries of Continental Western Europe to identify immunogenetic profiles of each SUD and evaluate their associations. The findings revealed two primary groupings of SUDs based on their immunogenetic profiles: one group comprised cannabis and cocaine, whereas the other group comprised alcohol, amphetamines, opioids, and “other” dependence. Since each individual possesses 12 HLA alleles, the population HLA-SUD scores were subsequently used to estimate individual risk for each SUD. Overall, the findings highlight similarities and differences in immunogenetic profiles of SUDs that may influence the prevalence and co-occurrence of problematic SUDs and may contribute to assessment of SUD risk of an individual on the basis of their HLA genetic makeup. Nature Publishing Group UK 2023-05-26 /pmc/articles/PMC10220069/ /pubmed/37237010 http://dx.doi.org/10.1038/s41598-023-35305-2 Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article James, Lisa M. Georgopoulos, Apostolos P. Risk assessment of substance use disorders based on the human leukocyte antigen (HLA) |
title | Risk assessment of substance use disorders based on the human leukocyte antigen (HLA) |
title_full | Risk assessment of substance use disorders based on the human leukocyte antigen (HLA) |
title_fullStr | Risk assessment of substance use disorders based on the human leukocyte antigen (HLA) |
title_full_unstemmed | Risk assessment of substance use disorders based on the human leukocyte antigen (HLA) |
title_short | Risk assessment of substance use disorders based on the human leukocyte antigen (HLA) |
title_sort | risk assessment of substance use disorders based on the human leukocyte antigen (hla) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220069/ https://www.ncbi.nlm.nih.gov/pubmed/37237010 http://dx.doi.org/10.1038/s41598-023-35305-2 |
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