SMARCB1 regulates a TFCP2L1-MYC transcriptional switch promoting renal medullary carcinoma transformation and ferroptosis resistance

Renal medullary carcinoma (RMC) is an aggressive tumour driven by bi-allelic loss of SMARCB1 and tightly associated with sickle cell trait. However, the cell-of-origin and oncogenic mechanism remain poorly understood. Using single-cell sequencing of human RMC, we defined transformation of thick asce...

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Detalles Bibliográficos
Autores principales: Vokshi, Bujamin H., Davidson, Guillaume, Tawanaie Pour Sedehi, Nassim, Helleux, Alexandra, Rippinger, Marc, Haller, Alexandre R., Gantzer, Justine, Thouvenin, Jonathan, Baltzinger, Philippe, Bouarich, Rachida, Manriquez, Valeria, Zaidi, Sakina, Rao, Priya, Msaouel, Pavlos, Su, Xiaoping, Lang, Hervé, Tricard, Thibault, Lindner, Véronique, Surdez, Didier, Kurtz, Jean-Emmanuel, Bourdeaut, Franck, Tannir, Nizar M., Davidson, Irwin, Malouf, Gabriel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220073/
https://www.ncbi.nlm.nih.gov/pubmed/37236926
http://dx.doi.org/10.1038/s41467-023-38472-y

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