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Evaluation of diversity indices to estimate clonal dominance in gene therapy studies
In cell and gene therapy, achieving the stable engraftment of an abundant and highly polyclonal population of gene-corrected cells is one of the key factors to ensure the successful and safe treatment of patients. Because integrative vectors have been associated with possible risks of insertional mu...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220254/ https://www.ncbi.nlm.nih.gov/pubmed/37251980 http://dx.doi.org/10.1016/j.omtm.2023.05.003 |