Ral GTPase promotes metastasis of pancreatic ductal adenocarcinoma via elevation of TGF-β1 production

Pancreatic ductal adenocarcinoma (PDAC), caused by activating mutations in K-Ras, is an aggressive malignancy due to its early invasion and metastasis. Ral GTPases are activated downstream of Ras and play a crucial role in the development and progression of PDAC. However, the underlying mechanisms r...

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Detalles Bibliográficos
Autores principales: Cao, Mingxin, Li, Xinming, Trinh, Duc-Anh, Yoshimachi, Shingo, Goto, Kota, Sakata, Natsumi, Ishida, Masaharu, Ohtsuka, Hideo, Unno, Michiaki, Wang, Yuxia, Shirakawa, Ryutaro, Horiuchi, Hisanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220265/
https://www.ncbi.nlm.nih.gov/pubmed/37116704
http://dx.doi.org/10.1016/j.jbc.2023.104754

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