Degradation of EGFR on lung epithelial cells by neutrophil elastase contributes to the aggravation of pneumococcal pneumonia

Pneumococcus is the main cause of bacterial pneumonia. Pneumococcal infection has been shown to cause elastase, an intracellular host defense factor, to leak from neutrophils. However, when neutrophil elastase (NE) leaks extracellularly, it can degrade host cell surface proteins such as epidermal gr...

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Detalles Bibliográficos
Autores principales: Isono, Toshihito, Hirayama, Satoru, Domon, Hisanori, Maekawa, Tomoki, Tamura, Hikaru, Hiyoshi, Takumi, Sirisereephap, Kridtapat, Takenaka, Shoji, Noiri, Yuichiro, Terao, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220274/
https://www.ncbi.nlm.nih.gov/pubmed/37119853
http://dx.doi.org/10.1016/j.jbc.2023.104760

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