Modified ASO conjugates encapsulated with cytidinyl/cationic lipids exhibit more potent and longer-lasting anti-HCC effects

Antisense oligonucleotides (ASOs) are a class of therapeutics targeting mRNAs or genes that have attracted much attention. However, effective delivery and optimal accumulation in target tissues in vivo are still challenging issues. CT102 is an ASO that targets IGF1R mRNA and induces cell apoptosis....

Descripción completa

Detalles Bibliográficos
Autores principales: Pan, Yufei, Guan, Jing, Gao, Yujing, Zhu, Yuejie, Li, Huantong, Guo, Hua, He, Qianyi, Guan, Zhu, Yang, Zhenjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220282/
https://www.ncbi.nlm.nih.gov/pubmed/37251692
http://dx.doi.org/10.1016/j.omtn.2023.04.028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220282/
https://www.ncbi.nlm.nih.gov/pubmed/37251692
http://dx.doi.org/10.1016/j.omtn.2023.04.028

Ejemplares similares