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Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4

Selenoprotein glutathione peroxidases (GPX), like ubiquitously expressed GPX1 and the ferroptosis modulator GPX4, enact antioxidant activities by reducing hydroperoxides using glutathione. Overexpression of these enzymes is common in cancer and can be associated with the development of resistance to...

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Detalles Bibliográficos
Autores principales:	Cheff, Dorian M., Cheng, Qing, Guo, Hui, Travers, Jameson, Klumpp-Thomas, Carleen, Shen, Min, Arnér, Elias S.J., Hall, Matthew D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220285/ https://www.ncbi.nlm.nih.gov/pubmed/37244126 http://dx.doi.org/10.1016/j.redox.2023.102719

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