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Importance of the neutrophil–lymphocyte ratio and systemic immune‐inflammation index in predicting colorectal pathologies in fecal occult blood‐positive patients
BACKGROUND: The fecal occult blood (FOB) test is one of the primary screening methods for colorectal cancer (CRC). In this study, we aimed to investigate the effect of the neutrophil/lymphocyte ratio (NLR) and systemic immune‐inflammation index (SII) in predicting CRC and other colorectal pathologie...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220293/ https://www.ncbi.nlm.nih.gov/pubmed/37096941 http://dx.doi.org/10.1002/jcla.24878 |
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author | Hasirci, Ismail Şahin, Alpaslan |
author_facet | Hasirci, Ismail Şahin, Alpaslan |
author_sort | Hasirci, Ismail |
collection | PubMed |
description | BACKGROUND: The fecal occult blood (FOB) test is one of the primary screening methods for colorectal cancer (CRC). In this study, we aimed to investigate the effect of the neutrophil/lymphocyte ratio (NLR) and systemic immune‐inflammation index (SII) in predicting CRC and other colorectal pathologies in patients with a positive FOB test. METHODS: This retrospective study included patients with a positive FOB test who underwent colonoscopy for the investigation of the etiology. The optimal cutoff levels of NLR and SII for predicting colorectal pathologies were determined using the receiver operating characteristic analysis. RESULTS: Of the 157 FOB+ patients, 35% were male and 65% were female, with a median age of 59 years. There were 96 patients in Group 1 and 61 patients in Group 2. The mean age of the patients in Group 2 was significantly higher (p < 0.001). The rate of male patients was significantly higher in Group 2. NLR and SII were significantly higher in Group 2 than in Group 1 (p < 0.001). The area under the curve values of NLR and SII in predicting colorectal pathologies in FOB+ patients were 0.817 and 0.825, respectively. At the cutoff values of 0.689 and 0.795, NLR and SII had a sensitivity of 60.66% and 95.83%, respectively, and a specificity of 95.83% and 100%, respectively. CONCLUSION: Neutrophil/lymphocyte ratio and SII can be used as important biomarkers in the early diagnosis of CRC and other colorectal lesions in patients with a positive FOB test. |
format | Online Article Text |
id | pubmed-10220293 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102202932023-05-28 Importance of the neutrophil–lymphocyte ratio and systemic immune‐inflammation index in predicting colorectal pathologies in fecal occult blood‐positive patients Hasirci, Ismail Şahin, Alpaslan J Clin Lab Anal Research Articles BACKGROUND: The fecal occult blood (FOB) test is one of the primary screening methods for colorectal cancer (CRC). In this study, we aimed to investigate the effect of the neutrophil/lymphocyte ratio (NLR) and systemic immune‐inflammation index (SII) in predicting CRC and other colorectal pathologies in patients with a positive FOB test. METHODS: This retrospective study included patients with a positive FOB test who underwent colonoscopy for the investigation of the etiology. The optimal cutoff levels of NLR and SII for predicting colorectal pathologies were determined using the receiver operating characteristic analysis. RESULTS: Of the 157 FOB+ patients, 35% were male and 65% were female, with a median age of 59 years. There were 96 patients in Group 1 and 61 patients in Group 2. The mean age of the patients in Group 2 was significantly higher (p < 0.001). The rate of male patients was significantly higher in Group 2. NLR and SII were significantly higher in Group 2 than in Group 1 (p < 0.001). The area under the curve values of NLR and SII in predicting colorectal pathologies in FOB+ patients were 0.817 and 0.825, respectively. At the cutoff values of 0.689 and 0.795, NLR and SII had a sensitivity of 60.66% and 95.83%, respectively, and a specificity of 95.83% and 100%, respectively. CONCLUSION: Neutrophil/lymphocyte ratio and SII can be used as important biomarkers in the early diagnosis of CRC and other colorectal lesions in patients with a positive FOB test. John Wiley and Sons Inc. 2023-04-25 /pmc/articles/PMC10220293/ /pubmed/37096941 http://dx.doi.org/10.1002/jcla.24878 Text en © 2023 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Hasirci, Ismail Şahin, Alpaslan Importance of the neutrophil–lymphocyte ratio and systemic immune‐inflammation index in predicting colorectal pathologies in fecal occult blood‐positive patients |
title | Importance of the neutrophil–lymphocyte ratio and systemic immune‐inflammation index in predicting colorectal pathologies in fecal occult blood‐positive patients |
title_full | Importance of the neutrophil–lymphocyte ratio and systemic immune‐inflammation index in predicting colorectal pathologies in fecal occult blood‐positive patients |
title_fullStr | Importance of the neutrophil–lymphocyte ratio and systemic immune‐inflammation index in predicting colorectal pathologies in fecal occult blood‐positive patients |
title_full_unstemmed | Importance of the neutrophil–lymphocyte ratio and systemic immune‐inflammation index in predicting colorectal pathologies in fecal occult blood‐positive patients |
title_short | Importance of the neutrophil–lymphocyte ratio and systemic immune‐inflammation index in predicting colorectal pathologies in fecal occult blood‐positive patients |
title_sort | importance of the neutrophil–lymphocyte ratio and systemic immune‐inflammation index in predicting colorectal pathologies in fecal occult blood‐positive patients |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220293/ https://www.ncbi.nlm.nih.gov/pubmed/37096941 http://dx.doi.org/10.1002/jcla.24878 |
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