Potential role of broad-spectrum azoles as therapy for Malasezzia bloodstream infection

Amphotericin B is the currently recommended therapy for Malassezia invasive infection (MII), but this drug requires intravenous administration and is associated with significant toxicity. The role of broad-spectrum azoles in managing MII is not clear. We describe two cases of MII due to M. pachyderm...

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Detalles Bibliográficos
Autores principales: Shah, Sunish, Nguyen, M. Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220303/
https://www.ncbi.nlm.nih.gov/pubmed/37251705
http://dx.doi.org/10.1016/j.mmcr.2023.05.002
Descripción
Sumario:Amphotericin B is the currently recommended therapy for Malassezia invasive infection (MII), but this drug requires intravenous administration and is associated with significant toxicity. The role of broad-spectrum azoles in managing MII is not clear. We describe two cases of MII due to M. pachydermatis and M. furfur that were successfully treated with posaconazole and reviewed the literature to assess the position of posaconazole in treating MII.

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