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Dietary fiber intake and mortality among survivors of liver cirrhosis: A prospective cohort study
BACKGROUND: Liver cirrhosis is associated with significant nutritional risks and poor survival rates. Little is known about the impact of dietary factors on metabolic complications and mortality from cirrhosis. AIM: The present study investigated the potential associations between dietary fibers and...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220317/ https://www.ncbi.nlm.nih.gov/pubmed/37251456 http://dx.doi.org/10.1016/j.heliyon.2023.e16170 |
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author | Hariri, Zahra Hekmatdoost, Azita Pashayee-khamene, Fereshteh Karimi, Sara Ahmadzadeh, Salehe Yari, Zahra |
author_facet | Hariri, Zahra Hekmatdoost, Azita Pashayee-khamene, Fereshteh Karimi, Sara Ahmadzadeh, Salehe Yari, Zahra |
author_sort | Hariri, Zahra |
collection | PubMed |
description | BACKGROUND: Liver cirrhosis is associated with significant nutritional risks and poor survival rates. Little is known about the impact of dietary factors on metabolic complications and mortality from cirrhosis. AIM: The present study investigated the potential associations between dietary fibers and the risk of cirrhosis-related mortality. METHODS: In this prospective study, 121 ambulatory cirrhotic patients with more than six months of cirrhosis diagnosis were followed-up for 4 years. Dietary intakes were assessed using a 168-item semi-quantitative validated food frequency questionnaire. Crude and multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated through cox proportional hazards regression models. RESULTS: Comparing the highest versus the lowest tertile, soluble and insoluble fiber intake was associated with 62% (HR = 0.38, 95% CI = 0.045–3.5, p trend = 0.047) and 73% (HR = 0.27, 95% CI = 0.06–1.2, p trend = 0.021) lower mortality risk, respectively, after full adjustment for potential confounders. Higher intakes of total fiber were inversely but non-significantly associated with mortality risk. CONCLUSION: Comprehensive assessment of dietary fiber intake associations with cirrhosis-related mortality showed that higher intakes of soluble and insoluble fiber were significantly associated with reduced mortality risk. |
format | Online Article Text |
id | pubmed-10220317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-102203172023-05-28 Dietary fiber intake and mortality among survivors of liver cirrhosis: A prospective cohort study Hariri, Zahra Hekmatdoost, Azita Pashayee-khamene, Fereshteh Karimi, Sara Ahmadzadeh, Salehe Yari, Zahra Heliyon Research Article BACKGROUND: Liver cirrhosis is associated with significant nutritional risks and poor survival rates. Little is known about the impact of dietary factors on metabolic complications and mortality from cirrhosis. AIM: The present study investigated the potential associations between dietary fibers and the risk of cirrhosis-related mortality. METHODS: In this prospective study, 121 ambulatory cirrhotic patients with more than six months of cirrhosis diagnosis were followed-up for 4 years. Dietary intakes were assessed using a 168-item semi-quantitative validated food frequency questionnaire. Crude and multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated through cox proportional hazards regression models. RESULTS: Comparing the highest versus the lowest tertile, soluble and insoluble fiber intake was associated with 62% (HR = 0.38, 95% CI = 0.045–3.5, p trend = 0.047) and 73% (HR = 0.27, 95% CI = 0.06–1.2, p trend = 0.021) lower mortality risk, respectively, after full adjustment for potential confounders. Higher intakes of total fiber were inversely but non-significantly associated with mortality risk. CONCLUSION: Comprehensive assessment of dietary fiber intake associations with cirrhosis-related mortality showed that higher intakes of soluble and insoluble fiber were significantly associated with reduced mortality risk. Elsevier 2023-05-09 /pmc/articles/PMC10220317/ /pubmed/37251456 http://dx.doi.org/10.1016/j.heliyon.2023.e16170 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research Article Hariri, Zahra Hekmatdoost, Azita Pashayee-khamene, Fereshteh Karimi, Sara Ahmadzadeh, Salehe Yari, Zahra Dietary fiber intake and mortality among survivors of liver cirrhosis: A prospective cohort study |
title | Dietary fiber intake and mortality among survivors of liver cirrhosis: A prospective cohort study |
title_full | Dietary fiber intake and mortality among survivors of liver cirrhosis: A prospective cohort study |
title_fullStr | Dietary fiber intake and mortality among survivors of liver cirrhosis: A prospective cohort study |
title_full_unstemmed | Dietary fiber intake and mortality among survivors of liver cirrhosis: A prospective cohort study |
title_short | Dietary fiber intake and mortality among survivors of liver cirrhosis: A prospective cohort study |
title_sort | dietary fiber intake and mortality among survivors of liver cirrhosis: a prospective cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220317/ https://www.ncbi.nlm.nih.gov/pubmed/37251456 http://dx.doi.org/10.1016/j.heliyon.2023.e16170 |
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