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Seeking a better understanding of the non-receptor tyrosine kinase, SRMS
SRMS (Src-Related kinase lacking C-terminal regulatory tyrosine and N-terminal Myristoylation Sites) is a non-receptor tyrosine kinase first reported in a 1994 screen for genes regulating murine neural precursor cells. SRMS, pronounced “Shrims”, lacks the C-terminal regulatory tyrosine critical for...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220380/ https://www.ncbi.nlm.nih.gov/pubmed/37251450 http://dx.doi.org/10.1016/j.heliyon.2023.e16421 |
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author | Goel, Raghuveera Kumar Kim, Nayoung Lukong, Kiven Erique |
author_facet | Goel, Raghuveera Kumar Kim, Nayoung Lukong, Kiven Erique |
author_sort | Goel, Raghuveera Kumar |
collection | PubMed |
description | SRMS (Src-Related kinase lacking C-terminal regulatory tyrosine and N-terminal Myristoylation Sites) is a non-receptor tyrosine kinase first reported in a 1994 screen for genes regulating murine neural precursor cells. SRMS, pronounced “Shrims”, lacks the C-terminal regulatory tyrosine critical for the regulation of the enzymatic activity of Src-family kinases (SFKs). Another remarkable characteristic of SRMS is its localization into distinct SRMS cytoplasmic punctae (SCPs) or GREL (Goel Raghuveera-Erique Lukong) bodies, a pattern not observed in the SFKs. This unique subcellular localization of SRMS could dictate its cellular targets, proteome, and potentially, substrates. However, the function of SRMS is still relatively unknown. Further, how is its activity regulated and by what cellular targets? Studies have emerged highlighting the potential role of SRMS in autophagy and in regulating the activation of BRK/PTK6. Potential novel cellular substrates have also been identified, including DOK1, vimentin, Sam68, FBKP51, and OTUB1. Recent studies have also demonstrated the potential role of the kinase in various cancers, including gastric and colorectal cancers and platinum resistance in ovarian cancer. This review discusses the advancements made in SRMS-related biology to date and the path to understanding the cellular and physiological significance of the kinase. |
format | Online Article Text |
id | pubmed-10220380 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-102203802023-05-28 Seeking a better understanding of the non-receptor tyrosine kinase, SRMS Goel, Raghuveera Kumar Kim, Nayoung Lukong, Kiven Erique Heliyon Review Article SRMS (Src-Related kinase lacking C-terminal regulatory tyrosine and N-terminal Myristoylation Sites) is a non-receptor tyrosine kinase first reported in a 1994 screen for genes regulating murine neural precursor cells. SRMS, pronounced “Shrims”, lacks the C-terminal regulatory tyrosine critical for the regulation of the enzymatic activity of Src-family kinases (SFKs). Another remarkable characteristic of SRMS is its localization into distinct SRMS cytoplasmic punctae (SCPs) or GREL (Goel Raghuveera-Erique Lukong) bodies, a pattern not observed in the SFKs. This unique subcellular localization of SRMS could dictate its cellular targets, proteome, and potentially, substrates. However, the function of SRMS is still relatively unknown. Further, how is its activity regulated and by what cellular targets? Studies have emerged highlighting the potential role of SRMS in autophagy and in regulating the activation of BRK/PTK6. Potential novel cellular substrates have also been identified, including DOK1, vimentin, Sam68, FBKP51, and OTUB1. Recent studies have also demonstrated the potential role of the kinase in various cancers, including gastric and colorectal cancers and platinum resistance in ovarian cancer. This review discusses the advancements made in SRMS-related biology to date and the path to understanding the cellular and physiological significance of the kinase. Elsevier 2023-05-20 /pmc/articles/PMC10220380/ /pubmed/37251450 http://dx.doi.org/10.1016/j.heliyon.2023.e16421 Text en © 2023 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Goel, Raghuveera Kumar Kim, Nayoung Lukong, Kiven Erique Seeking a better understanding of the non-receptor tyrosine kinase, SRMS |
title | Seeking a better understanding of the non-receptor tyrosine kinase, SRMS |
title_full | Seeking a better understanding of the non-receptor tyrosine kinase, SRMS |
title_fullStr | Seeking a better understanding of the non-receptor tyrosine kinase, SRMS |
title_full_unstemmed | Seeking a better understanding of the non-receptor tyrosine kinase, SRMS |
title_short | Seeking a better understanding of the non-receptor tyrosine kinase, SRMS |
title_sort | seeking a better understanding of the non-receptor tyrosine kinase, srms |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220380/ https://www.ncbi.nlm.nih.gov/pubmed/37251450 http://dx.doi.org/10.1016/j.heliyon.2023.e16421 |
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