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Comparison of the Effectiveness and Safety of Chlorthalidone and Hydrochlorothiazide in Patients With Hypertension: A Meta-Analysis

The aim of this study was to compare the effectiveness and safety of chlorthalidone and hydrochlorothiazide in patients with hypertension. The present meta-analysis was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Our search for re...

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Autores principales: Khenhrani, Raja Ram, Nnodebe, Ijeoma, Rawat, Anurag, Adwani, Rahul, Ghaffar, Ammara, Devi, Sapna, Afzal, Muhammad Sohaib, Usama, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220471/
https://www.ncbi.nlm.nih.gov/pubmed/37252566
http://dx.doi.org/10.7759/cureus.38184
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author Khenhrani, Raja Ram
Nnodebe, Ijeoma
Rawat, Anurag
Adwani, Rahul
Ghaffar, Ammara
Devi, Sapna
Afzal, Muhammad Sohaib
Usama, Muhammad
author_facet Khenhrani, Raja Ram
Nnodebe, Ijeoma
Rawat, Anurag
Adwani, Rahul
Ghaffar, Ammara
Devi, Sapna
Afzal, Muhammad Sohaib
Usama, Muhammad
author_sort Khenhrani, Raja Ram
collection PubMed
description The aim of this study was to compare the effectiveness and safety of chlorthalidone and hydrochlorothiazide in patients with hypertension. The present meta-analysis was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Our search for relevant articles was conducted on PubMed, Scopus, and CINAHIL databases from their inception until March 31, 2023. Keywords used to search for relevant articles included "hydrochlorothiazide," "chlortalidone," "hypertension," "cardiovascular," and "blood pressure." The outcomes assessed in this meta-analysis included changes in systolic blood pressure (SBP) and diastolic blood pressure (DBP). Myocardial infarction, stroke, and all-cause mortality were also assessed. For safety analysis, we evaluated the risk of hypokalemia between the two groups. Any disagreement between the two authors in the data extraction process was resolved through discussion. Eight studies fulfilled the inclusion criteria included in the present meta-analysis. Our analysis showed that chlorthalidone was superior to hydrochlorothiazide in controlling both SBP and DBP, with no significant heterogeneity reported. However, there was no significant difference between the two groups in terms of the risk of myocardial infarction, stroke, all-cause mortality, and hospitalization due to heart failure. The hypokalemia rate was reported to be higher with chlorthalidone compared to hydrochlorothiazide.
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spelling pubmed-102204712023-05-28 Comparison of the Effectiveness and Safety of Chlorthalidone and Hydrochlorothiazide in Patients With Hypertension: A Meta-Analysis Khenhrani, Raja Ram Nnodebe, Ijeoma Rawat, Anurag Adwani, Rahul Ghaffar, Ammara Devi, Sapna Afzal, Muhammad Sohaib Usama, Muhammad Cureus Cardiology The aim of this study was to compare the effectiveness and safety of chlorthalidone and hydrochlorothiazide in patients with hypertension. The present meta-analysis was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Our search for relevant articles was conducted on PubMed, Scopus, and CINAHIL databases from their inception until March 31, 2023. Keywords used to search for relevant articles included "hydrochlorothiazide," "chlortalidone," "hypertension," "cardiovascular," and "blood pressure." The outcomes assessed in this meta-analysis included changes in systolic blood pressure (SBP) and diastolic blood pressure (DBP). Myocardial infarction, stroke, and all-cause mortality were also assessed. For safety analysis, we evaluated the risk of hypokalemia between the two groups. Any disagreement between the two authors in the data extraction process was resolved through discussion. Eight studies fulfilled the inclusion criteria included in the present meta-analysis. Our analysis showed that chlorthalidone was superior to hydrochlorothiazide in controlling both SBP and DBP, with no significant heterogeneity reported. However, there was no significant difference between the two groups in terms of the risk of myocardial infarction, stroke, all-cause mortality, and hospitalization due to heart failure. The hypokalemia rate was reported to be higher with chlorthalidone compared to hydrochlorothiazide. Cureus 2023-04-27 /pmc/articles/PMC10220471/ /pubmed/37252566 http://dx.doi.org/10.7759/cureus.38184 Text en Copyright © 2023, Khenhrani et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Khenhrani, Raja Ram
Nnodebe, Ijeoma
Rawat, Anurag
Adwani, Rahul
Ghaffar, Ammara
Devi, Sapna
Afzal, Muhammad Sohaib
Usama, Muhammad
Comparison of the Effectiveness and Safety of Chlorthalidone and Hydrochlorothiazide in Patients With Hypertension: A Meta-Analysis
title Comparison of the Effectiveness and Safety of Chlorthalidone and Hydrochlorothiazide in Patients With Hypertension: A Meta-Analysis
title_full Comparison of the Effectiveness and Safety of Chlorthalidone and Hydrochlorothiazide in Patients With Hypertension: A Meta-Analysis
title_fullStr Comparison of the Effectiveness and Safety of Chlorthalidone and Hydrochlorothiazide in Patients With Hypertension: A Meta-Analysis
title_full_unstemmed Comparison of the Effectiveness and Safety of Chlorthalidone and Hydrochlorothiazide in Patients With Hypertension: A Meta-Analysis
title_short Comparison of the Effectiveness and Safety of Chlorthalidone and Hydrochlorothiazide in Patients With Hypertension: A Meta-Analysis
title_sort comparison of the effectiveness and safety of chlorthalidone and hydrochlorothiazide in patients with hypertension: a meta-analysis
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220471/
https://www.ncbi.nlm.nih.gov/pubmed/37252566
http://dx.doi.org/10.7759/cureus.38184
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