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Gender-Related Differences in the Levels of Ambulatory BP and Intensity of Antihypertensive Treatment in Patients Undergoing Peritoneal Dialysis

Prior studies have shown that among patients with chronic kidney disease not yet on dialysis, the faster progression of kidney injury in men than in women is, at least partly, explained by sex differences in ambulatory blood pressure (BP) control. The present study aimed to investigate potential dif...

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Autores principales: Kontogiorgos, Ioannis, Georgianos, Panagiotis I., Vaios, Vasilios, Vareta, Georgia, Georgianou, Eleni, Karligkiotis, Apostolos, Sgouropoulou, Vasiliki, Kantartzi, Konstantia, Zebekakis, Pantelis E., Liakopoulos, Vassilios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220551/
https://www.ncbi.nlm.nih.gov/pubmed/37240785
http://dx.doi.org/10.3390/life13051140
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author Kontogiorgos, Ioannis
Georgianos, Panagiotis I.
Vaios, Vasilios
Vareta, Georgia
Georgianou, Eleni
Karligkiotis, Apostolos
Sgouropoulou, Vasiliki
Kantartzi, Konstantia
Zebekakis, Pantelis E.
Liakopoulos, Vassilios
author_facet Kontogiorgos, Ioannis
Georgianos, Panagiotis I.
Vaios, Vasilios
Vareta, Georgia
Georgianou, Eleni
Karligkiotis, Apostolos
Sgouropoulou, Vasiliki
Kantartzi, Konstantia
Zebekakis, Pantelis E.
Liakopoulos, Vassilios
author_sort Kontogiorgos, Ioannis
collection PubMed
description Prior studies have shown that among patients with chronic kidney disease not yet on dialysis, the faster progression of kidney injury in men than in women is, at least partly, explained by sex differences in ambulatory blood pressure (BP) control. The present study aimed to investigate potential differences in the levels of ambulatory BP and intensity of antihypertensive treatment between men and women with end-stage kidney disease undergoing long-term peritoneal dialysis (PD). In a case-control design, 48 male PD patients were matched for age and heart failure status with 48 female patients in a 1:1 ratio. Ambulatory BP monitoring was performed with an oscillometric device, the Mobil-O-Graph (IEM, Stolberg, Germany). The BP-lowering medications actually taken by the patients were prospectively recorded. No gender-related differences were observed in 24 h systolic BP (129.0 ± 17.9 vs. 128.5 ± 17.6 mmHg, p = 0.890). In contrast, 24 h diastolic BP was higher in men than in women (81.5 ± 12.1 vs. 76.8 ± 10.3 mmHg, p = 0.042). As compared with women, men were being treated with a higher average number of antihypertensive medications daily (2.4 ± 1.1 vs. 1.9 ± 1.1, p = 0.019) and were more commonly receiving calcium-channel-blockers (70.8% vs. 43.8%, p = 0.007) and β-blockers (85.4% vs. 66.7%, p = 0.031). In conclusion, the present study shows that among PD patients, the levels of ambulatory BP and intensity of antihypertensive treatment are higher in men than in women. Longitudinal studies are needed to explore whether these gender-related differences in the severity of hypertension are associated with worse cardiovascular outcomes for male patients undergoing PD.
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spelling pubmed-102205512023-05-28 Gender-Related Differences in the Levels of Ambulatory BP and Intensity of Antihypertensive Treatment in Patients Undergoing Peritoneal Dialysis Kontogiorgos, Ioannis Georgianos, Panagiotis I. Vaios, Vasilios Vareta, Georgia Georgianou, Eleni Karligkiotis, Apostolos Sgouropoulou, Vasiliki Kantartzi, Konstantia Zebekakis, Pantelis E. Liakopoulos, Vassilios Life (Basel) Brief Report Prior studies have shown that among patients with chronic kidney disease not yet on dialysis, the faster progression of kidney injury in men than in women is, at least partly, explained by sex differences in ambulatory blood pressure (BP) control. The present study aimed to investigate potential differences in the levels of ambulatory BP and intensity of antihypertensive treatment between men and women with end-stage kidney disease undergoing long-term peritoneal dialysis (PD). In a case-control design, 48 male PD patients were matched for age and heart failure status with 48 female patients in a 1:1 ratio. Ambulatory BP monitoring was performed with an oscillometric device, the Mobil-O-Graph (IEM, Stolberg, Germany). The BP-lowering medications actually taken by the patients were prospectively recorded. No gender-related differences were observed in 24 h systolic BP (129.0 ± 17.9 vs. 128.5 ± 17.6 mmHg, p = 0.890). In contrast, 24 h diastolic BP was higher in men than in women (81.5 ± 12.1 vs. 76.8 ± 10.3 mmHg, p = 0.042). As compared with women, men were being treated with a higher average number of antihypertensive medications daily (2.4 ± 1.1 vs. 1.9 ± 1.1, p = 0.019) and were more commonly receiving calcium-channel-blockers (70.8% vs. 43.8%, p = 0.007) and β-blockers (85.4% vs. 66.7%, p = 0.031). In conclusion, the present study shows that among PD patients, the levels of ambulatory BP and intensity of antihypertensive treatment are higher in men than in women. Longitudinal studies are needed to explore whether these gender-related differences in the severity of hypertension are associated with worse cardiovascular outcomes for male patients undergoing PD. MDPI 2023-05-08 /pmc/articles/PMC10220551/ /pubmed/37240785 http://dx.doi.org/10.3390/life13051140 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Kontogiorgos, Ioannis
Georgianos, Panagiotis I.
Vaios, Vasilios
Vareta, Georgia
Georgianou, Eleni
Karligkiotis, Apostolos
Sgouropoulou, Vasiliki
Kantartzi, Konstantia
Zebekakis, Pantelis E.
Liakopoulos, Vassilios
Gender-Related Differences in the Levels of Ambulatory BP and Intensity of Antihypertensive Treatment in Patients Undergoing Peritoneal Dialysis
title Gender-Related Differences in the Levels of Ambulatory BP and Intensity of Antihypertensive Treatment in Patients Undergoing Peritoneal Dialysis
title_full Gender-Related Differences in the Levels of Ambulatory BP and Intensity of Antihypertensive Treatment in Patients Undergoing Peritoneal Dialysis
title_fullStr Gender-Related Differences in the Levels of Ambulatory BP and Intensity of Antihypertensive Treatment in Patients Undergoing Peritoneal Dialysis
title_full_unstemmed Gender-Related Differences in the Levels of Ambulatory BP and Intensity of Antihypertensive Treatment in Patients Undergoing Peritoneal Dialysis
title_short Gender-Related Differences in the Levels of Ambulatory BP and Intensity of Antihypertensive Treatment in Patients Undergoing Peritoneal Dialysis
title_sort gender-related differences in the levels of ambulatory bp and intensity of antihypertensive treatment in patients undergoing peritoneal dialysis
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220551/
https://www.ncbi.nlm.nih.gov/pubmed/37240785
http://dx.doi.org/10.3390/life13051140
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