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Advantages of Whole Genome Sequencing in Mitigating the Helicobacter pylori Antimicrobial Resistance Problem
Helicobacter pylori antimicrobial resistance is a critical public health issue. Typically, antimicrobial resistance epidemiology reports include only the antimicrobial susceptibility test results for H. pylori. However, this phenotypic approach is less capable of answering queries related to resista...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220574/ https://www.ncbi.nlm.nih.gov/pubmed/37317213 http://dx.doi.org/10.3390/microorganisms11051239 |
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author | Fauzia, Kartika Afrida Alfaray, Ricky Indra Yamaoka, Yoshio |
author_facet | Fauzia, Kartika Afrida Alfaray, Ricky Indra Yamaoka, Yoshio |
author_sort | Fauzia, Kartika Afrida |
collection | PubMed |
description | Helicobacter pylori antimicrobial resistance is a critical public health issue. Typically, antimicrobial resistance epidemiology reports include only the antimicrobial susceptibility test results for H. pylori. However, this phenotypic approach is less capable of answering queries related to resistance mechanisms and specific mutations found in particular global regions. Whole genome sequencing can help address these two questions while still offering quality control and is routinely validated against AST standards. A comprehensive understanding of the mechanisms of resistance should improve H. pylori eradication efforts and prevent gastric cancer. |
format | Online Article Text |
id | pubmed-10220574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102205742023-05-28 Advantages of Whole Genome Sequencing in Mitigating the Helicobacter pylori Antimicrobial Resistance Problem Fauzia, Kartika Afrida Alfaray, Ricky Indra Yamaoka, Yoshio Microorganisms Editorial Helicobacter pylori antimicrobial resistance is a critical public health issue. Typically, antimicrobial resistance epidemiology reports include only the antimicrobial susceptibility test results for H. pylori. However, this phenotypic approach is less capable of answering queries related to resistance mechanisms and specific mutations found in particular global regions. Whole genome sequencing can help address these two questions while still offering quality control and is routinely validated against AST standards. A comprehensive understanding of the mechanisms of resistance should improve H. pylori eradication efforts and prevent gastric cancer. MDPI 2023-05-08 /pmc/articles/PMC10220574/ /pubmed/37317213 http://dx.doi.org/10.3390/microorganisms11051239 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Editorial Fauzia, Kartika Afrida Alfaray, Ricky Indra Yamaoka, Yoshio Advantages of Whole Genome Sequencing in Mitigating the Helicobacter pylori Antimicrobial Resistance Problem |
title | Advantages of Whole Genome Sequencing in Mitigating the Helicobacter pylori Antimicrobial Resistance Problem |
title_full | Advantages of Whole Genome Sequencing in Mitigating the Helicobacter pylori Antimicrobial Resistance Problem |
title_fullStr | Advantages of Whole Genome Sequencing in Mitigating the Helicobacter pylori Antimicrobial Resistance Problem |
title_full_unstemmed | Advantages of Whole Genome Sequencing in Mitigating the Helicobacter pylori Antimicrobial Resistance Problem |
title_short | Advantages of Whole Genome Sequencing in Mitigating the Helicobacter pylori Antimicrobial Resistance Problem |
title_sort | advantages of whole genome sequencing in mitigating the helicobacter pylori antimicrobial resistance problem |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220574/ https://www.ncbi.nlm.nih.gov/pubmed/37317213 http://dx.doi.org/10.3390/microorganisms11051239 |
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