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Postoperative Hyperuricemia—A Risk Factor in Elective Cardiosurgical Patients
Hyperuricemia is a well-known cardiovascular risk factor. The aim of our study was to investigate the connection between postoperative hyperuricemia and poor outcomes after elective cardiac surgery compared to patients without postoperative hyperuricemia. In this retrospective study, a total of 227...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220585/ https://www.ncbi.nlm.nih.gov/pubmed/37233631 http://dx.doi.org/10.3390/metabo13050590 |
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author | Raos, Dominik Prkačin, Ingrid Delalić, Điđi Bulum, Tomislav Lovrić Benčić, Martina Jug, Juraj |
author_facet | Raos, Dominik Prkačin, Ingrid Delalić, Điđi Bulum, Tomislav Lovrić Benčić, Martina Jug, Juraj |
author_sort | Raos, Dominik |
collection | PubMed |
description | Hyperuricemia is a well-known cardiovascular risk factor. The aim of our study was to investigate the connection between postoperative hyperuricemia and poor outcomes after elective cardiac surgery compared to patients without postoperative hyperuricemia. In this retrospective study, a total of 227 patients after elective cardiac surgery were divided into two groups: 42 patients with postoperative hyperuricemia (mean age 65.14 ± 8.9 years) and a second group of 185 patients without it (mean age 62.67 ± 7.45 years). The time spent on mechanical ventilation (hours) and in the intensive care unit (days) were taken as the primary outcome measures while the secondary measure comprised postoperative complications. The preoperative patient characteristics were similar. Most of the patients were men. The EuroSCORE value of assessing the risk was not different between the groups nor the comorbidities. Among the most common comorbidities was hypertension, seen in 66% of all patients (69% in patients with postoperative hyperuricemia and 63.7% in those without it). A group of patients with postoperative hyperuricemia had a prolonged time of treatment in the intensive care unit (p = 0.03), as well as a prolonged duration of mechanical ventilation (p < 0.01) and a significantly higher incidence of the following postoperative complications: circulatory instability and/or low cardiac output syndrome (LCOS) (χ2 = 4486, p < 0.01), renal failure and/or continuous venovenous hemodiafiltration (CVVHDF’s) (χ2 = 10,241, p < 0.001), and mortality (χ2 = 5.22, p < 0.01). Compared to patients without postoperative hyperuricemia, elective cardiac patients with postoperative hyperuricemia have prolonged postoperative treatment in intensive care units, extended durations of mechanically assisted ventilation, and a higher incidence of postoperative circulatory instability, renal failure, and death. |
format | Online Article Text |
id | pubmed-10220585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102205852023-05-28 Postoperative Hyperuricemia—A Risk Factor in Elective Cardiosurgical Patients Raos, Dominik Prkačin, Ingrid Delalić, Điđi Bulum, Tomislav Lovrić Benčić, Martina Jug, Juraj Metabolites Article Hyperuricemia is a well-known cardiovascular risk factor. The aim of our study was to investigate the connection between postoperative hyperuricemia and poor outcomes after elective cardiac surgery compared to patients without postoperative hyperuricemia. In this retrospective study, a total of 227 patients after elective cardiac surgery were divided into two groups: 42 patients with postoperative hyperuricemia (mean age 65.14 ± 8.9 years) and a second group of 185 patients without it (mean age 62.67 ± 7.45 years). The time spent on mechanical ventilation (hours) and in the intensive care unit (days) were taken as the primary outcome measures while the secondary measure comprised postoperative complications. The preoperative patient characteristics were similar. Most of the patients were men. The EuroSCORE value of assessing the risk was not different between the groups nor the comorbidities. Among the most common comorbidities was hypertension, seen in 66% of all patients (69% in patients with postoperative hyperuricemia and 63.7% in those without it). A group of patients with postoperative hyperuricemia had a prolonged time of treatment in the intensive care unit (p = 0.03), as well as a prolonged duration of mechanical ventilation (p < 0.01) and a significantly higher incidence of the following postoperative complications: circulatory instability and/or low cardiac output syndrome (LCOS) (χ2 = 4486, p < 0.01), renal failure and/or continuous venovenous hemodiafiltration (CVVHDF’s) (χ2 = 10,241, p < 0.001), and mortality (χ2 = 5.22, p < 0.01). Compared to patients without postoperative hyperuricemia, elective cardiac patients with postoperative hyperuricemia have prolonged postoperative treatment in intensive care units, extended durations of mechanically assisted ventilation, and a higher incidence of postoperative circulatory instability, renal failure, and death. MDPI 2023-04-25 /pmc/articles/PMC10220585/ /pubmed/37233631 http://dx.doi.org/10.3390/metabo13050590 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Raos, Dominik Prkačin, Ingrid Delalić, Điđi Bulum, Tomislav Lovrić Benčić, Martina Jug, Juraj Postoperative Hyperuricemia—A Risk Factor in Elective Cardiosurgical Patients |
title | Postoperative Hyperuricemia—A Risk Factor in Elective Cardiosurgical Patients |
title_full | Postoperative Hyperuricemia—A Risk Factor in Elective Cardiosurgical Patients |
title_fullStr | Postoperative Hyperuricemia—A Risk Factor in Elective Cardiosurgical Patients |
title_full_unstemmed | Postoperative Hyperuricemia—A Risk Factor in Elective Cardiosurgical Patients |
title_short | Postoperative Hyperuricemia—A Risk Factor in Elective Cardiosurgical Patients |
title_sort | postoperative hyperuricemia—a risk factor in elective cardiosurgical patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220585/ https://www.ncbi.nlm.nih.gov/pubmed/37233631 http://dx.doi.org/10.3390/metabo13050590 |
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