Acquired Von Willebrand Factor Deficiency at Patient-Prosthesis Mismatch after AVR Procedure—A Narrative Review

Acquired von Willebrand factor deficiency has been described in patients with aortic valve stenosis due to high shear forces developed during passage through the narrowed valve orifice, which determines structural changes in this molecule. Similar flow conditions are present in patients with an aort...

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Detalles Bibliográficos
Autores principales: Grigorescu, Andrei Emanuel, Anghel, Andrei, Buriman, Darius Gheorghe, Feier, Horea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220691/
https://www.ncbi.nlm.nih.gov/pubmed/37241186
http://dx.doi.org/10.3390/medicina59050954
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author Grigorescu, Andrei Emanuel
Anghel, Andrei
Buriman, Darius Gheorghe
Feier, Horea
author_facet Grigorescu, Andrei Emanuel
Anghel, Andrei
Buriman, Darius Gheorghe
Feier, Horea
author_sort Grigorescu, Andrei Emanuel
collection PubMed
description Acquired von Willebrand factor deficiency has been described in patients with aortic valve stenosis due to high shear forces developed during passage through the narrowed valve orifice, which determines structural changes in this molecule. Similar flow conditions are present in patients with an aortic prosthesis that presents a patient-prosthesis mismatch. Patient-prosthesis mismatch is described by the smaller effective orifice area of the prosthesis than the native valve, which would probably determine similar changes in the molecules of the von Willebrand factor, leading to acquiring von Willebrand deficiency.
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spelling pubmed-102206912023-05-28 Acquired Von Willebrand Factor Deficiency at Patient-Prosthesis Mismatch after AVR Procedure—A Narrative Review Grigorescu, Andrei Emanuel Anghel, Andrei Buriman, Darius Gheorghe Feier, Horea Medicina (Kaunas) Review Acquired von Willebrand factor deficiency has been described in patients with aortic valve stenosis due to high shear forces developed during passage through the narrowed valve orifice, which determines structural changes in this molecule. Similar flow conditions are present in patients with an aortic prosthesis that presents a patient-prosthesis mismatch. Patient-prosthesis mismatch is described by the smaller effective orifice area of the prosthesis than the native valve, which would probably determine similar changes in the molecules of the von Willebrand factor, leading to acquiring von Willebrand deficiency. MDPI 2023-05-16 /pmc/articles/PMC10220691/ /pubmed/37241186 http://dx.doi.org/10.3390/medicina59050954 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Grigorescu, Andrei Emanuel
Anghel, Andrei
Buriman, Darius Gheorghe
Feier, Horea
Acquired Von Willebrand Factor Deficiency at Patient-Prosthesis Mismatch after AVR Procedure—A Narrative Review
title Acquired Von Willebrand Factor Deficiency at Patient-Prosthesis Mismatch after AVR Procedure—A Narrative Review
title_full Acquired Von Willebrand Factor Deficiency at Patient-Prosthesis Mismatch after AVR Procedure—A Narrative Review
title_fullStr Acquired Von Willebrand Factor Deficiency at Patient-Prosthesis Mismatch after AVR Procedure—A Narrative Review
title_full_unstemmed Acquired Von Willebrand Factor Deficiency at Patient-Prosthesis Mismatch after AVR Procedure—A Narrative Review
title_short Acquired Von Willebrand Factor Deficiency at Patient-Prosthesis Mismatch after AVR Procedure—A Narrative Review
title_sort acquired von willebrand factor deficiency at patient-prosthesis mismatch after avr procedure—a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220691/
https://www.ncbi.nlm.nih.gov/pubmed/37241186
http://dx.doi.org/10.3390/medicina59050954
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