Design, Synthesis, and Biological Evaluation of Marine Lissodendrins B Analogues as Modulators of ABCB1-Mediated Multidrug Resistance

Multidrug resistance (MDR) caused by ATP-Binding Cassette Subfamily B Member 1 (ABCB1, P-glycoprotein, P-gp) is a major barrier for the success of chemotherapy in clinics. In this study, we designed and synthesized a total of 19 Lissodendrins B analogues and tested their ABCB1-mediated MDR reversal...

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Detalles Bibliográficos
Autores principales: Wang, Chaoming, Zhang, Jinman, Wei, Xianfeng, Yang, Mengke, Ma, Weiping, Yu, Rilei, Liu, Ming, Jiang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220702/
https://www.ncbi.nlm.nih.gov/pubmed/37233508
http://dx.doi.org/10.3390/md21050314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220702/
https://www.ncbi.nlm.nih.gov/pubmed/37233508
http://dx.doi.org/10.3390/md21050314

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