Cargando…

Surveillance of Viral Respiratory Infections in the Neonatal Intensive Care Unit—Evolution in the Last 5 Years

Viral respiratory infections (VRIs) in very low birthweight infants can be associated with high rates of morbidity. The COVID-19 pandemic has exerted a strong impact on viral circulation. The purpose of this study is to report on VRIs during NICU admission in infants below 32 weeks’ gestation and co...

Descripción completa

Detalles Bibliográficos
Autores principales: Bravo-Queipo-de-Llano, Blanca, Sánchez García, Laura, Casas, Inmaculada, Pozo, Francisco, La Banda, Leticia, Alcolea, Sonia, Atucha, Jorge, Sánchez-León, Rocío, Pellicer, Adelina, Calvo, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220719/
https://www.ncbi.nlm.nih.gov/pubmed/37242314
http://dx.doi.org/10.3390/pathogens12050644
_version_ 1785049284861755392
author Bravo-Queipo-de-Llano, Blanca
Sánchez García, Laura
Casas, Inmaculada
Pozo, Francisco
La Banda, Leticia
Alcolea, Sonia
Atucha, Jorge
Sánchez-León, Rocío
Pellicer, Adelina
Calvo, Cristina
author_facet Bravo-Queipo-de-Llano, Blanca
Sánchez García, Laura
Casas, Inmaculada
Pozo, Francisco
La Banda, Leticia
Alcolea, Sonia
Atucha, Jorge
Sánchez-León, Rocío
Pellicer, Adelina
Calvo, Cristina
author_sort Bravo-Queipo-de-Llano, Blanca
collection PubMed
description Viral respiratory infections (VRIs) in very low birthweight infants can be associated with high rates of morbidity. The COVID-19 pandemic has exerted a strong impact on viral circulation. The purpose of this study is to report on VRIs during NICU admission in infants below 32 weeks’ gestation and compare data collected between the pre-and post-COVID-19 pandemic periods. A prospective surveillance study was conducted at a tertiary NICU between April 2016 and June 2022. The COVID-19 post-pandemic period was established as being from March 2020 onwards. Respiratory virus detection was performed by real-time multiplex PCR assays in nasopharyngeal aspirates (NPAs). A total of 366 infants were enrolled. There were no statistical differences between periods regarding infants’ birth weight, gestational age, gender distribution, or rates of bronchopulmonary dysplasia. Among the 1589 NPA collected during the pre-COVID-19 period, 8.9% were positive, and among the 1147 NPA collected during the post-pandemic period, only 3% were positive (p < 0.005). The type of viruses detected did not differ according to the study period (pre-COVID19 vs. post-COVID-19): rhinovirus (49.5% vs. 37.5%), adenovirus (22.6% vs. 25%), and human coronavirus (12.9% vs. 16.7%). SARS-CoV-2 was only detected in one patient. In conclusion, the viral profile causing VRI during the pre-COVID-19 and post-COVID-19 era was similar. However, the total number of VRI dropped significantly, most probably due to the global increase in infection prevention measures.
format Online
Article
Text
id pubmed-10220719
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102207192023-05-28 Surveillance of Viral Respiratory Infections in the Neonatal Intensive Care Unit—Evolution in the Last 5 Years Bravo-Queipo-de-Llano, Blanca Sánchez García, Laura Casas, Inmaculada Pozo, Francisco La Banda, Leticia Alcolea, Sonia Atucha, Jorge Sánchez-León, Rocío Pellicer, Adelina Calvo, Cristina Pathogens Brief Report Viral respiratory infections (VRIs) in very low birthweight infants can be associated with high rates of morbidity. The COVID-19 pandemic has exerted a strong impact on viral circulation. The purpose of this study is to report on VRIs during NICU admission in infants below 32 weeks’ gestation and compare data collected between the pre-and post-COVID-19 pandemic periods. A prospective surveillance study was conducted at a tertiary NICU between April 2016 and June 2022. The COVID-19 post-pandemic period was established as being from March 2020 onwards. Respiratory virus detection was performed by real-time multiplex PCR assays in nasopharyngeal aspirates (NPAs). A total of 366 infants were enrolled. There were no statistical differences between periods regarding infants’ birth weight, gestational age, gender distribution, or rates of bronchopulmonary dysplasia. Among the 1589 NPA collected during the pre-COVID-19 period, 8.9% were positive, and among the 1147 NPA collected during the post-pandemic period, only 3% were positive (p < 0.005). The type of viruses detected did not differ according to the study period (pre-COVID19 vs. post-COVID-19): rhinovirus (49.5% vs. 37.5%), adenovirus (22.6% vs. 25%), and human coronavirus (12.9% vs. 16.7%). SARS-CoV-2 was only detected in one patient. In conclusion, the viral profile causing VRI during the pre-COVID-19 and post-COVID-19 era was similar. However, the total number of VRI dropped significantly, most probably due to the global increase in infection prevention measures. MDPI 2023-04-27 /pmc/articles/PMC10220719/ /pubmed/37242314 http://dx.doi.org/10.3390/pathogens12050644 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Bravo-Queipo-de-Llano, Blanca
Sánchez García, Laura
Casas, Inmaculada
Pozo, Francisco
La Banda, Leticia
Alcolea, Sonia
Atucha, Jorge
Sánchez-León, Rocío
Pellicer, Adelina
Calvo, Cristina
Surveillance of Viral Respiratory Infections in the Neonatal Intensive Care Unit—Evolution in the Last 5 Years
title Surveillance of Viral Respiratory Infections in the Neonatal Intensive Care Unit—Evolution in the Last 5 Years
title_full Surveillance of Viral Respiratory Infections in the Neonatal Intensive Care Unit—Evolution in the Last 5 Years
title_fullStr Surveillance of Viral Respiratory Infections in the Neonatal Intensive Care Unit—Evolution in the Last 5 Years
title_full_unstemmed Surveillance of Viral Respiratory Infections in the Neonatal Intensive Care Unit—Evolution in the Last 5 Years
title_short Surveillance of Viral Respiratory Infections in the Neonatal Intensive Care Unit—Evolution in the Last 5 Years
title_sort surveillance of viral respiratory infections in the neonatal intensive care unit—evolution in the last 5 years
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220719/
https://www.ncbi.nlm.nih.gov/pubmed/37242314
http://dx.doi.org/10.3390/pathogens12050644
work_keys_str_mv AT bravoqueipodellanoblanca surveillanceofviralrespiratoryinfectionsintheneonatalintensivecareunitevolutioninthelast5years
AT sanchezgarcialaura surveillanceofviralrespiratoryinfectionsintheneonatalintensivecareunitevolutioninthelast5years
AT casasinmaculada surveillanceofviralrespiratoryinfectionsintheneonatalintensivecareunitevolutioninthelast5years
AT pozofrancisco surveillanceofviralrespiratoryinfectionsintheneonatalintensivecareunitevolutioninthelast5years
AT labandaleticia surveillanceofviralrespiratoryinfectionsintheneonatalintensivecareunitevolutioninthelast5years
AT alcoleasonia surveillanceofviralrespiratoryinfectionsintheneonatalintensivecareunitevolutioninthelast5years
AT atuchajorge surveillanceofviralrespiratoryinfectionsintheneonatalintensivecareunitevolutioninthelast5years
AT sanchezleonrocio surveillanceofviralrespiratoryinfectionsintheneonatalintensivecareunitevolutioninthelast5years
AT pelliceradelina surveillanceofviralrespiratoryinfectionsintheneonatalintensivecareunitevolutioninthelast5years
AT calvocristina surveillanceofviralrespiratoryinfectionsintheneonatalintensivecareunitevolutioninthelast5years