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Depression and Anxiety in Heart Transplant Recipients: Prevalence and Impact on Post-Transplant Outcomes
Background: Depression and anxiety (DA) are common mental disorders in patients with chronic diseases, but the research regarding their prevalence in heart transplantation (HTx) is still limited. Methods: We performed an analysis of the prevalence and prognostic relevance of DA in patients who under...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220721/ https://www.ncbi.nlm.nih.gov/pubmed/37241014 http://dx.doi.org/10.3390/jpm13050844 |
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author | Alyaydin, Emyal Sindermann, Juergen Reinhard Köppe, Jeanette Gerss, Joachim Dröge, Patrik Ruhnke, Thomas Günster, Christian Reinecke, Holger Feld, Jannik |
author_facet | Alyaydin, Emyal Sindermann, Juergen Reinhard Köppe, Jeanette Gerss, Joachim Dröge, Patrik Ruhnke, Thomas Günster, Christian Reinecke, Holger Feld, Jannik |
author_sort | Alyaydin, Emyal |
collection | PubMed |
description | Background: Depression and anxiety (DA) are common mental disorders in patients with chronic diseases, but the research regarding their prevalence in heart transplantation (HTx) is still limited. Methods: We performed an analysis of the prevalence and prognostic relevance of DA in patients who underwent HTx between 2010 and 2018 in Germany. Data were obtained from Allgemeine Ortskrankenkasse (AOK), which is the largest public health insurance provider. Results: Overall, 694 patients were identified. More than a third of them were diagnosed with DA before undergoing HTx (n = 260, 37.5%). Patients with DA more often had an ischaemic cardiomyopathy (p < 0.001) and a history of previous myocardial infarction (p = 0.001) or stroke (p = 0.002). The prevalence of hypertension (p < 0.001), diabetes (p = 0.004), dyslipidaemia (p < 0.001) and chronic kidney disease (p = 0.003) was higher amongst transplant recipients with DA. Patients with DA were more likely to suffer an ischaemic stroke (p < 0.001) or haemorrhagic stroke (p = 0.032), or develop septicaemia (p = 0.050) during hospitalisation for HTx. Our analysis found no significant differences between the groups with respect to in-hospital mortality. The female sex and mechanical circulatory support were associated with an inferior prognosis. Pretransplant non-ischaemic cardiomyopathy was related to a favourable outcome. Conclusions: DA affect up to a third of the population undergoing HTx, with a greater prevalence in patients with comorbidities. DA are associated with a higher incidence of stroke and septicaemia after HTx. |
format | Online Article Text |
id | pubmed-10220721 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102207212023-05-28 Depression and Anxiety in Heart Transplant Recipients: Prevalence and Impact on Post-Transplant Outcomes Alyaydin, Emyal Sindermann, Juergen Reinhard Köppe, Jeanette Gerss, Joachim Dröge, Patrik Ruhnke, Thomas Günster, Christian Reinecke, Holger Feld, Jannik J Pers Med Article Background: Depression and anxiety (DA) are common mental disorders in patients with chronic diseases, but the research regarding their prevalence in heart transplantation (HTx) is still limited. Methods: We performed an analysis of the prevalence and prognostic relevance of DA in patients who underwent HTx between 2010 and 2018 in Germany. Data were obtained from Allgemeine Ortskrankenkasse (AOK), which is the largest public health insurance provider. Results: Overall, 694 patients were identified. More than a third of them were diagnosed with DA before undergoing HTx (n = 260, 37.5%). Patients with DA more often had an ischaemic cardiomyopathy (p < 0.001) and a history of previous myocardial infarction (p = 0.001) or stroke (p = 0.002). The prevalence of hypertension (p < 0.001), diabetes (p = 0.004), dyslipidaemia (p < 0.001) and chronic kidney disease (p = 0.003) was higher amongst transplant recipients with DA. Patients with DA were more likely to suffer an ischaemic stroke (p < 0.001) or haemorrhagic stroke (p = 0.032), or develop septicaemia (p = 0.050) during hospitalisation for HTx. Our analysis found no significant differences between the groups with respect to in-hospital mortality. The female sex and mechanical circulatory support were associated with an inferior prognosis. Pretransplant non-ischaemic cardiomyopathy was related to a favourable outcome. Conclusions: DA affect up to a third of the population undergoing HTx, with a greater prevalence in patients with comorbidities. DA are associated with a higher incidence of stroke and septicaemia after HTx. MDPI 2023-05-17 /pmc/articles/PMC10220721/ /pubmed/37241014 http://dx.doi.org/10.3390/jpm13050844 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Alyaydin, Emyal Sindermann, Juergen Reinhard Köppe, Jeanette Gerss, Joachim Dröge, Patrik Ruhnke, Thomas Günster, Christian Reinecke, Holger Feld, Jannik Depression and Anxiety in Heart Transplant Recipients: Prevalence and Impact on Post-Transplant Outcomes |
title | Depression and Anxiety in Heart Transplant Recipients: Prevalence and Impact on Post-Transplant Outcomes |
title_full | Depression and Anxiety in Heart Transplant Recipients: Prevalence and Impact on Post-Transplant Outcomes |
title_fullStr | Depression and Anxiety in Heart Transplant Recipients: Prevalence and Impact on Post-Transplant Outcomes |
title_full_unstemmed | Depression and Anxiety in Heart Transplant Recipients: Prevalence and Impact on Post-Transplant Outcomes |
title_short | Depression and Anxiety in Heart Transplant Recipients: Prevalence and Impact on Post-Transplant Outcomes |
title_sort | depression and anxiety in heart transplant recipients: prevalence and impact on post-transplant outcomes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220721/ https://www.ncbi.nlm.nih.gov/pubmed/37241014 http://dx.doi.org/10.3390/jpm13050844 |
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