Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population

Interleukin-6 has been recognized as a major role player in COVID-19 severity, being an important regulator of the cytokine storm. Hence, the evaluation of the influence of polymorphisms in key genes of the IL-6 pathway, namely IL6, IL6R, and IL6ST, may provide valuable prognostic/predictive markers...

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Detalles Bibliográficos
Autores principales: Rodrigues, Fabíola Brasil Barbosa, da Silva, Rosilene, dos Santos, Erika Ferreira, de Brito, Mioni Thieli Figueiredo Magalhães, da Silva, Andréa Luciana Soares, de Meira Leite, Mauro, Póvoa da Costa, Flávia, de Nazaré do Socorro de Almeida Viana, Maria, de Sarges, Kevin Matheus Lima, Cantanhede, Marcos Henrique Damasceno, Veríssimo, Adriana de Oliveira Lameira, Carvalho, Mayara da Silva, Henriques, Daniele Freitas, da Silva, Carla Pinheiro, Costa, Igor Brasil, Nunes, Juliana Abreu Lima, Costa, Iran Barros, Viana, Giselle Maria Rachid, Queiroz, Maria Alice Freitas, Lima, Sandra Souza, Lopes, Jeferson da Costa, Torres, Maria Karoliny da Silva, Vallinoto, Izaura Maria Vieira Cayres, Bichara, Carlos David Araújo, Vallinoto, Antonio Carlos Rosário, dos Santos, Eduardo José Melo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220739/
https://www.ncbi.nlm.nih.gov/pubmed/37243282
http://dx.doi.org/10.3390/v15051197
Descripción
Sumario:Interleukin-6 has been recognized as a major role player in COVID-19 severity, being an important regulator of the cytokine storm. Hence, the evaluation of the influence of polymorphisms in key genes of the IL-6 pathway, namely IL6, IL6R, and IL6ST, may provide valuable prognostic/predictive markers for COVID-19. The present cross-sectional study genotyped three SNPs (rs1800795, rs2228145, and rs7730934) at IL6. IL6R and IL6ST genes, respectively, in 227 COVID-19 patients (132 hospitalized and 95 non-hospitalized). Genotype frequencies were compared between these groups. As a control group, published data on gene and genotype frequencies were gathered from published studies before the pandemic started. Our major results point to an association of the IL6 C allele with COVID-19 severity. Moreover, IL-6 plasmatic levels were higher among IL6 CC genotype carriers. Additionally, the frequency of symptoms was higher at IL6 CC and IL6R CC genotypes. In conclusion, the data suggest an important role of IL6 C allele and IL6R CC genotype on COVID-19 severity, in agreement with indirect evidence from the literature about the association of these genotypes with mortality rates, pneumonia, and heightening of protein plasmatic levels pro-inflammatory driven effects.

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