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Pharmacokinetic Feasibility of Stability-Enhanced Solid-State (SESS) Tenofovir Disoproxil Free Base Crystal

Tenofovir (TEV) is a nucleotide reverse transcriptase inhibitor used against human immunodeficiency virus (HIV) reverse transcriptase. To improve the poor bioavailability of TEV, TEV disoproxil (TD), an ester prodrug of TEV, was developed, and TD fumarate (TDF; Viread(®)) has been marketed due to th...

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Detalles Bibliográficos
Autores principales:	You, Byoung Hoon, Bae, Mingoo, Han, Seung Yon, Jung, Jieun, Jung, Kiwon, Choi, Young Hee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220743/ https://www.ncbi.nlm.nih.gov/pubmed/37242634 http://dx.doi.org/10.3390/pharmaceutics15051392

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