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Age, Sex and BMI Relations with Anti-SARS-CoV-2-Spike IgG Antibodies after BNT162b2 COVID-19 Vaccine in Health Care Workers in Northern Greece

The aim of this work was to study age, sex, and BMI (Body Mass Index)-related differences in the development of anti-SARS-CoV-2-Spike IgG antibodies, after vaccination with the BNT162b2 COVID-19 vaccine, in health care workers of a General Hospital in a city in Northern Greece. Blood sampling was dr...

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Autores principales: Papaioannidou, Paraskevi, Skoumpa, Kalypso, Bostanitis, Christos, Michailidou, Maria, Stergiopoulou, Theodouli, Bostanitis, Ioannis, Tsalidou, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220759/
https://www.ncbi.nlm.nih.gov/pubmed/37317253
http://dx.doi.org/10.3390/microorganisms11051279
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author Papaioannidou, Paraskevi
Skoumpa, Kalypso
Bostanitis, Christos
Michailidou, Maria
Stergiopoulou, Theodouli
Bostanitis, Ioannis
Tsalidou, Maria
author_facet Papaioannidou, Paraskevi
Skoumpa, Kalypso
Bostanitis, Christos
Michailidou, Maria
Stergiopoulou, Theodouli
Bostanitis, Ioannis
Tsalidou, Maria
author_sort Papaioannidou, Paraskevi
collection PubMed
description The aim of this work was to study age, sex, and BMI (Body Mass Index)-related differences in the development of anti-SARS-CoV-2-Spike IgG antibodies, after vaccination with the BNT162b2 COVID-19 vaccine, in health care workers of a General Hospital in a city in Northern Greece. Blood sampling was drawn two to four weeks following the second dose of the vaccine, and six months after the first blood sample collection. Measurement of serum IgG antibodies against the spike domain of SARS-CoV-2 was performed using the SARS-CoV-2 IgG II Quant assay. All participants had sufficient serum IgG titers in the first measurement. Women developed higher IgG titers than men. The IgG titers were inversely related to age in both sexes; there was also a small, insignificant tendency to be inversely related to BMI. Six months after the first measurement, the IgG titers decreased dramatically to values less than 5% of the initial. This decrease was observed in both men and women and was inversely related to age. Multivariate regression analysis showed that age and sex explained with statistical significance 9% of the variance in SARS-CoV-2 IgG titers in our study population; the role of BMI was limited and insignificant.
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spelling pubmed-102207592023-05-28 Age, Sex and BMI Relations with Anti-SARS-CoV-2-Spike IgG Antibodies after BNT162b2 COVID-19 Vaccine in Health Care Workers in Northern Greece Papaioannidou, Paraskevi Skoumpa, Kalypso Bostanitis, Christos Michailidou, Maria Stergiopoulou, Theodouli Bostanitis, Ioannis Tsalidou, Maria Microorganisms Article The aim of this work was to study age, sex, and BMI (Body Mass Index)-related differences in the development of anti-SARS-CoV-2-Spike IgG antibodies, after vaccination with the BNT162b2 COVID-19 vaccine, in health care workers of a General Hospital in a city in Northern Greece. Blood sampling was drawn two to four weeks following the second dose of the vaccine, and six months after the first blood sample collection. Measurement of serum IgG antibodies against the spike domain of SARS-CoV-2 was performed using the SARS-CoV-2 IgG II Quant assay. All participants had sufficient serum IgG titers in the first measurement. Women developed higher IgG titers than men. The IgG titers were inversely related to age in both sexes; there was also a small, insignificant tendency to be inversely related to BMI. Six months after the first measurement, the IgG titers decreased dramatically to values less than 5% of the initial. This decrease was observed in both men and women and was inversely related to age. Multivariate regression analysis showed that age and sex explained with statistical significance 9% of the variance in SARS-CoV-2 IgG titers in our study population; the role of BMI was limited and insignificant. MDPI 2023-05-13 /pmc/articles/PMC10220759/ /pubmed/37317253 http://dx.doi.org/10.3390/microorganisms11051279 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Papaioannidou, Paraskevi
Skoumpa, Kalypso
Bostanitis, Christos
Michailidou, Maria
Stergiopoulou, Theodouli
Bostanitis, Ioannis
Tsalidou, Maria
Age, Sex and BMI Relations with Anti-SARS-CoV-2-Spike IgG Antibodies after BNT162b2 COVID-19 Vaccine in Health Care Workers in Northern Greece
title Age, Sex and BMI Relations with Anti-SARS-CoV-2-Spike IgG Antibodies after BNT162b2 COVID-19 Vaccine in Health Care Workers in Northern Greece
title_full Age, Sex and BMI Relations with Anti-SARS-CoV-2-Spike IgG Antibodies after BNT162b2 COVID-19 Vaccine in Health Care Workers in Northern Greece
title_fullStr Age, Sex and BMI Relations with Anti-SARS-CoV-2-Spike IgG Antibodies after BNT162b2 COVID-19 Vaccine in Health Care Workers in Northern Greece
title_full_unstemmed Age, Sex and BMI Relations with Anti-SARS-CoV-2-Spike IgG Antibodies after BNT162b2 COVID-19 Vaccine in Health Care Workers in Northern Greece
title_short Age, Sex and BMI Relations with Anti-SARS-CoV-2-Spike IgG Antibodies after BNT162b2 COVID-19 Vaccine in Health Care Workers in Northern Greece
title_sort age, sex and bmi relations with anti-sars-cov-2-spike igg antibodies after bnt162b2 covid-19 vaccine in health care workers in northern greece
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220759/
https://www.ncbi.nlm.nih.gov/pubmed/37317253
http://dx.doi.org/10.3390/microorganisms11051279
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