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Carbapenem-Resistant Pseudomonas aeruginosa Bacteremia, through a Six-Year Infection Control Program in a Hospital

Background: Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a life-threatening healthcare-associated infection affecting especially patients with immunosuppression and comorbidities. We investigated the association between the incidence of CRPA bacteremia, antibiotic consumption, and infection...

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Autores principales: Papanikolopoulou, Amalia, Gargalianos-Kakolyris, Panagiotis, Stoupis, Athina, Moussas, Nikos, Pangalis, Anastasia, Theodoridou, Kalliopi, Chronopoulou, Genovefa, Pantazis, Nikos, Kantzanou, Maria, Maltezou, Helena C., Tsakris, Athanasios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220838/
https://www.ncbi.nlm.nih.gov/pubmed/37317288
http://dx.doi.org/10.3390/microorganisms11051315
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author Papanikolopoulou, Amalia
Gargalianos-Kakolyris, Panagiotis
Stoupis, Athina
Moussas, Nikos
Pangalis, Anastasia
Theodoridou, Kalliopi
Chronopoulou, Genovefa
Pantazis, Nikos
Kantzanou, Maria
Maltezou, Helena C.
Tsakris, Athanasios
author_facet Papanikolopoulou, Amalia
Gargalianos-Kakolyris, Panagiotis
Stoupis, Athina
Moussas, Nikos
Pangalis, Anastasia
Theodoridou, Kalliopi
Chronopoulou, Genovefa
Pantazis, Nikos
Kantzanou, Maria
Maltezou, Helena C.
Tsakris, Athanasios
author_sort Papanikolopoulou, Amalia
collection PubMed
description Background: Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a life-threatening healthcare-associated infection affecting especially patients with immunosuppression and comorbidities. We investigated the association between the incidence of CRPA bacteremia, antibiotic consumption, and infection control measures in a hospital during 2013–2018. Methods: We prospectively recorded the incidence of CRPA bacteremia, antibiotic consumption, use of hand-hygiene solutions, and isolation rates of multidrug-resistant (MDR) carrier patients. Findings: The consumption of colistin, aminoglycosides, and third-generation cephalosporins decreased significantly in the total hospital and its divisions (p-value < 0.001 for all comparisons) while the consumption of carbapenems decreased significantly in the adults ICU (p-value = 0.025). In addition, the incidence of CRPA significantly decreased in the total hospital clinics and departments (p-values = 0.027 and 0.042, respectively) and in adults clinics and departments (p-values = 0.031 and 0.051, respectively), while in the adults ICU, the incidence remained unchanged. Increased isolation rates of MDR carrier patients, even two months before, significantly correlated with decreased incidence of CRPA bacteremia (IRR: 0.20, 95% CI: 0.05–0.73, p-value = 0.015) in the adults ICU. Interestingly, when the use of hand-hygiene solutions (alcohol and/or scrub) increased, the consumption of advanced, nonadvanced, and all antibiotics decreased significantly. Conclusion: In our hospital, multimodal infection control interventions resulted in a significant reduction of CRPA bacteremia, mostly due to the reduction of all classes of antibiotics.
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spelling pubmed-102208382023-05-28 Carbapenem-Resistant Pseudomonas aeruginosa Bacteremia, through a Six-Year Infection Control Program in a Hospital Papanikolopoulou, Amalia Gargalianos-Kakolyris, Panagiotis Stoupis, Athina Moussas, Nikos Pangalis, Anastasia Theodoridou, Kalliopi Chronopoulou, Genovefa Pantazis, Nikos Kantzanou, Maria Maltezou, Helena C. Tsakris, Athanasios Microorganisms Article Background: Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a life-threatening healthcare-associated infection affecting especially patients with immunosuppression and comorbidities. We investigated the association between the incidence of CRPA bacteremia, antibiotic consumption, and infection control measures in a hospital during 2013–2018. Methods: We prospectively recorded the incidence of CRPA bacteremia, antibiotic consumption, use of hand-hygiene solutions, and isolation rates of multidrug-resistant (MDR) carrier patients. Findings: The consumption of colistin, aminoglycosides, and third-generation cephalosporins decreased significantly in the total hospital and its divisions (p-value < 0.001 for all comparisons) while the consumption of carbapenems decreased significantly in the adults ICU (p-value = 0.025). In addition, the incidence of CRPA significantly decreased in the total hospital clinics and departments (p-values = 0.027 and 0.042, respectively) and in adults clinics and departments (p-values = 0.031 and 0.051, respectively), while in the adults ICU, the incidence remained unchanged. Increased isolation rates of MDR carrier patients, even two months before, significantly correlated with decreased incidence of CRPA bacteremia (IRR: 0.20, 95% CI: 0.05–0.73, p-value = 0.015) in the adults ICU. Interestingly, when the use of hand-hygiene solutions (alcohol and/or scrub) increased, the consumption of advanced, nonadvanced, and all antibiotics decreased significantly. Conclusion: In our hospital, multimodal infection control interventions resulted in a significant reduction of CRPA bacteremia, mostly due to the reduction of all classes of antibiotics. MDPI 2023-05-17 /pmc/articles/PMC10220838/ /pubmed/37317288 http://dx.doi.org/10.3390/microorganisms11051315 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Papanikolopoulou, Amalia
Gargalianos-Kakolyris, Panagiotis
Stoupis, Athina
Moussas, Nikos
Pangalis, Anastasia
Theodoridou, Kalliopi
Chronopoulou, Genovefa
Pantazis, Nikos
Kantzanou, Maria
Maltezou, Helena C.
Tsakris, Athanasios
Carbapenem-Resistant Pseudomonas aeruginosa Bacteremia, through a Six-Year Infection Control Program in a Hospital
title Carbapenem-Resistant Pseudomonas aeruginosa Bacteremia, through a Six-Year Infection Control Program in a Hospital
title_full Carbapenem-Resistant Pseudomonas aeruginosa Bacteremia, through a Six-Year Infection Control Program in a Hospital
title_fullStr Carbapenem-Resistant Pseudomonas aeruginosa Bacteremia, through a Six-Year Infection Control Program in a Hospital
title_full_unstemmed Carbapenem-Resistant Pseudomonas aeruginosa Bacteremia, through a Six-Year Infection Control Program in a Hospital
title_short Carbapenem-Resistant Pseudomonas aeruginosa Bacteremia, through a Six-Year Infection Control Program in a Hospital
title_sort carbapenem-resistant pseudomonas aeruginosa bacteremia, through a six-year infection control program in a hospital
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220838/
https://www.ncbi.nlm.nih.gov/pubmed/37317288
http://dx.doi.org/10.3390/microorganisms11051315
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