Permeability of Metformin across an In Vitro Blood–Brain Barrier Model during Normoxia and Oxygen-Glucose Deprivation Conditions: Role of Organic Cation Transporters (Octs)

Our lab previously established that metformin, a first-line type two diabetes treatment, activates the Nrf2 pathway and improves post-stroke recovery. Metformin’s brain permeability value and potential interaction with blood–brain barrier (BBB) uptake and efflux transporters are currently unknown. M...

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Detalles Bibliográficos
Autores principales: Sharma, Sejal, Zhang, Yong, Akter, Khondker Ayesha, Nozohouri, Saeideh, Archie, Sabrina Rahman, Patel, Dhavalkumar, Villalba, Heidi, Abbruscato, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220878/
https://www.ncbi.nlm.nih.gov/pubmed/37242599
http://dx.doi.org/10.3390/pharmaceutics15051357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220878/
https://www.ncbi.nlm.nih.gov/pubmed/37242599
http://dx.doi.org/10.3390/pharmaceutics15051357

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