Cargando…

Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery

Constantly evolving drug-resistant “superbugs” have caused an urgent demand for novel antimicrobial agents. Natural products and their analogs have been a prolific source of antimicrobial agents, even though a high rediscovery rate and less targeted research has made the field challenging in the pre...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Yuehan, Kessler, Mara Grace C., Marchán-Rivadeneira, Maria Raquel, Han, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221052/
https://www.ncbi.nlm.nih.gov/pubmed/37241928
http://dx.doi.org/10.3390/molecules28104183
_version_ 1785049364252590080
author Yang, Yuehan
Kessler, Mara Grace C.
Marchán-Rivadeneira, Maria Raquel
Han, Yong
author_facet Yang, Yuehan
Kessler, Mara Grace C.
Marchán-Rivadeneira, Maria Raquel
Han, Yong
author_sort Yang, Yuehan
collection PubMed
description Constantly evolving drug-resistant “superbugs” have caused an urgent demand for novel antimicrobial agents. Natural products and their analogs have been a prolific source of antimicrobial agents, even though a high rediscovery rate and less targeted research has made the field challenging in the pre-genomic era. With recent advancements in technology, natural product research is gaining new life. Genome mining has allowed for more targeted excavation of biosynthetic potential from natural sources that was previously overlooked. Researchers use bioinformatic algorithms to rapidly identify and predict antimicrobial candidates by studying the genome before even entering the lab. In addition, synthetic biology and advanced analytical instruments enable the accelerated identification of novel antibiotics with distinct structures. Here, we reviewed the literature for noteworthy examples of novel antimicrobial agents discovered through various methodologies, highlighting the candidates with potent effectiveness against antimicrobial-resistant pathogens.
format Online
Article
Text
id pubmed-10221052
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102210522023-05-28 Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery Yang, Yuehan Kessler, Mara Grace C. Marchán-Rivadeneira, Maria Raquel Han, Yong Molecules Review Constantly evolving drug-resistant “superbugs” have caused an urgent demand for novel antimicrobial agents. Natural products and their analogs have been a prolific source of antimicrobial agents, even though a high rediscovery rate and less targeted research has made the field challenging in the pre-genomic era. With recent advancements in technology, natural product research is gaining new life. Genome mining has allowed for more targeted excavation of biosynthetic potential from natural sources that was previously overlooked. Researchers use bioinformatic algorithms to rapidly identify and predict antimicrobial candidates by studying the genome before even entering the lab. In addition, synthetic biology and advanced analytical instruments enable the accelerated identification of novel antibiotics with distinct structures. Here, we reviewed the literature for noteworthy examples of novel antimicrobial agents discovered through various methodologies, highlighting the candidates with potent effectiveness against antimicrobial-resistant pathogens. MDPI 2023-05-19 /pmc/articles/PMC10221052/ /pubmed/37241928 http://dx.doi.org/10.3390/molecules28104183 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yang, Yuehan
Kessler, Mara Grace C.
Marchán-Rivadeneira, Maria Raquel
Han, Yong
Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery
title Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery
title_full Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery
title_fullStr Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery
title_full_unstemmed Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery
title_short Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery
title_sort combating antimicrobial resistance in the post-genomic era: rapid antibiotic discovery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221052/
https://www.ncbi.nlm.nih.gov/pubmed/37241928
http://dx.doi.org/10.3390/molecules28104183
work_keys_str_mv AT yangyuehan combatingantimicrobialresistanceinthepostgenomicerarapidantibioticdiscovery
AT kesslermaragracec combatingantimicrobialresistanceinthepostgenomicerarapidantibioticdiscovery
AT marchanrivadeneiramariaraquel combatingantimicrobialresistanceinthepostgenomicerarapidantibioticdiscovery
AT hanyong combatingantimicrobialresistanceinthepostgenomicerarapidantibioticdiscovery