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Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery
Constantly evolving drug-resistant “superbugs” have caused an urgent demand for novel antimicrobial agents. Natural products and their analogs have been a prolific source of antimicrobial agents, even though a high rediscovery rate and less targeted research has made the field challenging in the pre...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221052/ https://www.ncbi.nlm.nih.gov/pubmed/37241928 http://dx.doi.org/10.3390/molecules28104183 |
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author | Yang, Yuehan Kessler, Mara Grace C. Marchán-Rivadeneira, Maria Raquel Han, Yong |
author_facet | Yang, Yuehan Kessler, Mara Grace C. Marchán-Rivadeneira, Maria Raquel Han, Yong |
author_sort | Yang, Yuehan |
collection | PubMed |
description | Constantly evolving drug-resistant “superbugs” have caused an urgent demand for novel antimicrobial agents. Natural products and their analogs have been a prolific source of antimicrobial agents, even though a high rediscovery rate and less targeted research has made the field challenging in the pre-genomic era. With recent advancements in technology, natural product research is gaining new life. Genome mining has allowed for more targeted excavation of biosynthetic potential from natural sources that was previously overlooked. Researchers use bioinformatic algorithms to rapidly identify and predict antimicrobial candidates by studying the genome before even entering the lab. In addition, synthetic biology and advanced analytical instruments enable the accelerated identification of novel antibiotics with distinct structures. Here, we reviewed the literature for noteworthy examples of novel antimicrobial agents discovered through various methodologies, highlighting the candidates with potent effectiveness against antimicrobial-resistant pathogens. |
format | Online Article Text |
id | pubmed-10221052 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102210522023-05-28 Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery Yang, Yuehan Kessler, Mara Grace C. Marchán-Rivadeneira, Maria Raquel Han, Yong Molecules Review Constantly evolving drug-resistant “superbugs” have caused an urgent demand for novel antimicrobial agents. Natural products and their analogs have been a prolific source of antimicrobial agents, even though a high rediscovery rate and less targeted research has made the field challenging in the pre-genomic era. With recent advancements in technology, natural product research is gaining new life. Genome mining has allowed for more targeted excavation of biosynthetic potential from natural sources that was previously overlooked. Researchers use bioinformatic algorithms to rapidly identify and predict antimicrobial candidates by studying the genome before even entering the lab. In addition, synthetic biology and advanced analytical instruments enable the accelerated identification of novel antibiotics with distinct structures. Here, we reviewed the literature for noteworthy examples of novel antimicrobial agents discovered through various methodologies, highlighting the candidates with potent effectiveness against antimicrobial-resistant pathogens. MDPI 2023-05-19 /pmc/articles/PMC10221052/ /pubmed/37241928 http://dx.doi.org/10.3390/molecules28104183 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yang, Yuehan Kessler, Mara Grace C. Marchán-Rivadeneira, Maria Raquel Han, Yong Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery |
title | Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery |
title_full | Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery |
title_fullStr | Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery |
title_full_unstemmed | Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery |
title_short | Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery |
title_sort | combating antimicrobial resistance in the post-genomic era: rapid antibiotic discovery |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221052/ https://www.ncbi.nlm.nih.gov/pubmed/37241928 http://dx.doi.org/10.3390/molecules28104183 |
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