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Impact of Maternal Lifestyle and Dietary Habits during Pregnancy on Newborn Metabolic Profile

Expanded newborn screening (NBS) is a preventive program that allows for the early identification of over 40 congenital endocrine-metabolic diseases by analyzing dried blood spot samples collected from the newborn’s heel within 48–72 h of birth. The determination of amino acids and acyl-carnitines b...

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Detalles Bibliográficos
Autores principales: Cicalini, Ilaria, Moffa, Samanta, Tommolini, Maria Lucia, Valentinuzzi, Silvia, Zucchelli, Mirco, Bucci, Ines, Chiacchiaretta, Piero, Fontana, Antonella, Federici, Luca, De Laurenzi, Vincenzo, Del Boccio, Piero, Rossi, Claudia, Pieragostino, Damiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221063/
https://www.ncbi.nlm.nih.gov/pubmed/37242180
http://dx.doi.org/10.3390/nu15102297
Descripción
Sumario:Expanded newborn screening (NBS) is a preventive program that allows for the early identification of over 40 congenital endocrine-metabolic diseases by analyzing dried blood spot samples collected from the newborn’s heel within 48–72 h of birth. The determination of amino acids and acyl-carnitines by Flow Injection Analysis Tandem Mass Spectrometry (FIA-MS/MS) may also highlight metabolic alterations resulting from external factors, such as maternal nutrition. In the present study, we developed a questionnaire to investigate the eating habits of 109 women during pregnancy and statistically correlated the results from the investigation on dietary habits with the data obtained by the NBS laboratory of Abruzzo region (Italy). Parameters such as smoking, physical activity, and the intake of iodized salt, drugs, and supplements were analyzed. This study aimed to highlight how maternal lifestyle, diet, and drug intake during pregnancy may affect the neonatal metabolic profile, possibly generating false positive or false negative results in the NBS test. The results pointed out how the knowledge of maternal nutrition and lifestyle may also be precious in preventing misinterpretations of the neonatal metabolic profile, thereby reducing unnecessary stress for newborns and their parents and limiting costs for the health system.