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Impact of Maternal Lifestyle and Dietary Habits during Pregnancy on Newborn Metabolic Profile
Expanded newborn screening (NBS) is a preventive program that allows for the early identification of over 40 congenital endocrine-metabolic diseases by analyzing dried blood spot samples collected from the newborn’s heel within 48–72 h of birth. The determination of amino acids and acyl-carnitines b...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221063/ https://www.ncbi.nlm.nih.gov/pubmed/37242180 http://dx.doi.org/10.3390/nu15102297 |
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author | Cicalini, Ilaria Moffa, Samanta Tommolini, Maria Lucia Valentinuzzi, Silvia Zucchelli, Mirco Bucci, Ines Chiacchiaretta, Piero Fontana, Antonella Federici, Luca De Laurenzi, Vincenzo Del Boccio, Piero Rossi, Claudia Pieragostino, Damiana |
author_facet | Cicalini, Ilaria Moffa, Samanta Tommolini, Maria Lucia Valentinuzzi, Silvia Zucchelli, Mirco Bucci, Ines Chiacchiaretta, Piero Fontana, Antonella Federici, Luca De Laurenzi, Vincenzo Del Boccio, Piero Rossi, Claudia Pieragostino, Damiana |
author_sort | Cicalini, Ilaria |
collection | PubMed |
description | Expanded newborn screening (NBS) is a preventive program that allows for the early identification of over 40 congenital endocrine-metabolic diseases by analyzing dried blood spot samples collected from the newborn’s heel within 48–72 h of birth. The determination of amino acids and acyl-carnitines by Flow Injection Analysis Tandem Mass Spectrometry (FIA-MS/MS) may also highlight metabolic alterations resulting from external factors, such as maternal nutrition. In the present study, we developed a questionnaire to investigate the eating habits of 109 women during pregnancy and statistically correlated the results from the investigation on dietary habits with the data obtained by the NBS laboratory of Abruzzo region (Italy). Parameters such as smoking, physical activity, and the intake of iodized salt, drugs, and supplements were analyzed. This study aimed to highlight how maternal lifestyle, diet, and drug intake during pregnancy may affect the neonatal metabolic profile, possibly generating false positive or false negative results in the NBS test. The results pointed out how the knowledge of maternal nutrition and lifestyle may also be precious in preventing misinterpretations of the neonatal metabolic profile, thereby reducing unnecessary stress for newborns and their parents and limiting costs for the health system. |
format | Online Article Text |
id | pubmed-10221063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102210632023-05-28 Impact of Maternal Lifestyle and Dietary Habits during Pregnancy on Newborn Metabolic Profile Cicalini, Ilaria Moffa, Samanta Tommolini, Maria Lucia Valentinuzzi, Silvia Zucchelli, Mirco Bucci, Ines Chiacchiaretta, Piero Fontana, Antonella Federici, Luca De Laurenzi, Vincenzo Del Boccio, Piero Rossi, Claudia Pieragostino, Damiana Nutrients Article Expanded newborn screening (NBS) is a preventive program that allows for the early identification of over 40 congenital endocrine-metabolic diseases by analyzing dried blood spot samples collected from the newborn’s heel within 48–72 h of birth. The determination of amino acids and acyl-carnitines by Flow Injection Analysis Tandem Mass Spectrometry (FIA-MS/MS) may also highlight metabolic alterations resulting from external factors, such as maternal nutrition. In the present study, we developed a questionnaire to investigate the eating habits of 109 women during pregnancy and statistically correlated the results from the investigation on dietary habits with the data obtained by the NBS laboratory of Abruzzo region (Italy). Parameters such as smoking, physical activity, and the intake of iodized salt, drugs, and supplements were analyzed. This study aimed to highlight how maternal lifestyle, diet, and drug intake during pregnancy may affect the neonatal metabolic profile, possibly generating false positive or false negative results in the NBS test. The results pointed out how the knowledge of maternal nutrition and lifestyle may also be precious in preventing misinterpretations of the neonatal metabolic profile, thereby reducing unnecessary stress for newborns and their parents and limiting costs for the health system. MDPI 2023-05-13 /pmc/articles/PMC10221063/ /pubmed/37242180 http://dx.doi.org/10.3390/nu15102297 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cicalini, Ilaria Moffa, Samanta Tommolini, Maria Lucia Valentinuzzi, Silvia Zucchelli, Mirco Bucci, Ines Chiacchiaretta, Piero Fontana, Antonella Federici, Luca De Laurenzi, Vincenzo Del Boccio, Piero Rossi, Claudia Pieragostino, Damiana Impact of Maternal Lifestyle and Dietary Habits during Pregnancy on Newborn Metabolic Profile |
title | Impact of Maternal Lifestyle and Dietary Habits during Pregnancy on Newborn Metabolic Profile |
title_full | Impact of Maternal Lifestyle and Dietary Habits during Pregnancy on Newborn Metabolic Profile |
title_fullStr | Impact of Maternal Lifestyle and Dietary Habits during Pregnancy on Newborn Metabolic Profile |
title_full_unstemmed | Impact of Maternal Lifestyle and Dietary Habits during Pregnancy on Newborn Metabolic Profile |
title_short | Impact of Maternal Lifestyle and Dietary Habits during Pregnancy on Newborn Metabolic Profile |
title_sort | impact of maternal lifestyle and dietary habits during pregnancy on newborn metabolic profile |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221063/ https://www.ncbi.nlm.nih.gov/pubmed/37242180 http://dx.doi.org/10.3390/nu15102297 |
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