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Interactions of Equine Viruses with the Host Kinase Machinery and Implications for One Health and Human Disease
Zoonotic pathogens that are vector-transmitted have and continue to contribute to several emerging infections globally. In recent years, spillover events of such zoonotic pathogens have increased in frequency as a result of direct contact with livestock, wildlife, and urbanization, forcing animals f...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221139/ https://www.ncbi.nlm.nih.gov/pubmed/37243249 http://dx.doi.org/10.3390/v15051163 |
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author | Anderson, Carol Baha, Haseebullah Boghdeh, Niloufar Barrera, Michael Alem, Farhang Narayanan, Aarthi |
author_facet | Anderson, Carol Baha, Haseebullah Boghdeh, Niloufar Barrera, Michael Alem, Farhang Narayanan, Aarthi |
author_sort | Anderson, Carol |
collection | PubMed |
description | Zoonotic pathogens that are vector-transmitted have and continue to contribute to several emerging infections globally. In recent years, spillover events of such zoonotic pathogens have increased in frequency as a result of direct contact with livestock, wildlife, and urbanization, forcing animals from their natural habitats. Equines serve as reservoir hosts for vector-transmitted zoonotic viruses that are also capable of infecting humans and causing disease. From a One Health perspective, equine viruses, therefore, pose major concerns for periodic outbreaks globally. Several equine viruses have spread out of their indigenous regions, such as West Nile virus (WNV) and equine encephalitis viruses (EEVs), making them of paramount concern to public health. Viruses have evolved many mechanisms to support the establishment of productive infection and to avoid host defense mechanisms, including promoting or decreasing inflammatory responses and regulating host machinery for protein synthesis. Viral interactions with the host enzymatic machinery, specifically kinases, can support the viral infectious process and downplay innate immune mechanisms, cumulatively leading to a more severe course of the disease. In this review, we will focus on how select equine viruses interact with host kinases to support viral multiplication. |
format | Online Article Text |
id | pubmed-10221139 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102211392023-05-28 Interactions of Equine Viruses with the Host Kinase Machinery and Implications for One Health and Human Disease Anderson, Carol Baha, Haseebullah Boghdeh, Niloufar Barrera, Michael Alem, Farhang Narayanan, Aarthi Viruses Review Zoonotic pathogens that are vector-transmitted have and continue to contribute to several emerging infections globally. In recent years, spillover events of such zoonotic pathogens have increased in frequency as a result of direct contact with livestock, wildlife, and urbanization, forcing animals from their natural habitats. Equines serve as reservoir hosts for vector-transmitted zoonotic viruses that are also capable of infecting humans and causing disease. From a One Health perspective, equine viruses, therefore, pose major concerns for periodic outbreaks globally. Several equine viruses have spread out of their indigenous regions, such as West Nile virus (WNV) and equine encephalitis viruses (EEVs), making them of paramount concern to public health. Viruses have evolved many mechanisms to support the establishment of productive infection and to avoid host defense mechanisms, including promoting or decreasing inflammatory responses and regulating host machinery for protein synthesis. Viral interactions with the host enzymatic machinery, specifically kinases, can support the viral infectious process and downplay innate immune mechanisms, cumulatively leading to a more severe course of the disease. In this review, we will focus on how select equine viruses interact with host kinases to support viral multiplication. MDPI 2023-05-13 /pmc/articles/PMC10221139/ /pubmed/37243249 http://dx.doi.org/10.3390/v15051163 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Anderson, Carol Baha, Haseebullah Boghdeh, Niloufar Barrera, Michael Alem, Farhang Narayanan, Aarthi Interactions of Equine Viruses with the Host Kinase Machinery and Implications for One Health and Human Disease |
title | Interactions of Equine Viruses with the Host Kinase Machinery and Implications for One Health and Human Disease |
title_full | Interactions of Equine Viruses with the Host Kinase Machinery and Implications for One Health and Human Disease |
title_fullStr | Interactions of Equine Viruses with the Host Kinase Machinery and Implications for One Health and Human Disease |
title_full_unstemmed | Interactions of Equine Viruses with the Host Kinase Machinery and Implications for One Health and Human Disease |
title_short | Interactions of Equine Viruses with the Host Kinase Machinery and Implications for One Health and Human Disease |
title_sort | interactions of equine viruses with the host kinase machinery and implications for one health and human disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221139/ https://www.ncbi.nlm.nih.gov/pubmed/37243249 http://dx.doi.org/10.3390/v15051163 |
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