Optimizing the Production of gp145, an HIV-1 Envelope Glycoprotein Vaccine Candidate and Its Encapsulation in Guanosine Microparticles

We have developed a pipeline to express, purify, and characterize HIV envelope protein (Env) gp145 from Chinese hamster ovary cells, to accelerate the production of a promising vaccine candidate. First in shake flasks, then in bioreactors, we optimized the growth conditions. By adjusting the pH to 6...

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Detalles Bibliográficos
Autores principales: Akamine, Pearl, González-Feliciano, José A., Almodóvar, Ruth, Morell, Gloriner, Rivera, Javier, Capó-Vélez, Coral M., Delgado-Vélez, Manuel, Prieto-Costas, Luis, Madera, Bismark, Eichinger, Daniel, Pino, Ignacio, Rivera, José H., Ortiz-Ubarri, José, Rivera, José M., Baerga-Ortiz, Abel, Lasalde-Dominicci, José A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221277/
https://www.ncbi.nlm.nih.gov/pubmed/37243079
http://dx.doi.org/10.3390/vaccines11050975

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