Cargando…

A First-in-Human Trial to Evaluate the Safety and Immunogenicity of a G Protein-Based Recombinant Respiratory Syncytial Virus Vaccine in Healthy Adults 18–45 Years of Age

Background: With the enormous morbidity and mortality caused by respiratory syncytial virus (RSV) infections among infants and the elderly, vaccines against RSV infections are in large market demand. Methods: We conducted a first-in-human (FIH), randomized, double-blind, placebo-controlled dose esca...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Xin, Zhao, Gan, Dong, Aihua, He, Zhonghuai, Wang, Jiarong, Jiang, Brian, Wang, Bo, Wang, Miaomiao, Huai, Xuefen, Zhang, Shijie, Feng, Shuangshuang, Qin, Hong, Wang, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221330/ https://www.ncbi.nlm.nih.gov/pubmed/37243103 http://dx.doi.org/10.3390/vaccines11050999

Ejemplares similares

Neonatal priming and infancy boosting with a novel respiratory syncytial virus vaccine induces protective immune responses without concomitant respiratory disease upon RSV challenge
por: Zhang, Shuren, et al.
Publicado: (2019)

Combinatorial F-G Immunogens as Nipah and Respiratory Syncytial Virus Vaccine Candidates
por: Isaacs, Ariel, et al.
Publicado: (2021)

Structure-Based Design and Antigenic Validation of Respiratory Syncytial Virus G Immunogens
por: Nuñez Castrejon, Ana M., et al.
Publicado: (2022)

Development of a reverse genetics system for respiratory syncytial virus long strain and an immunogenicity study of the recombinant virus
por: Hu, Bing, et al.
Publicado: (2014)

Immunogenicity and inflammatory properties of respiratory syncytial virus attachment G protein in cotton rats
por: Martinez, Margaret E., et al.
Publicado: (2021)

A Recombinant BCG Vaccine Is Safe and Immunogenic in Neonatal Calves and Reduces the Clinical Disease Caused by the Respiratory Syncytial Virus
por: Díaz, Fabián E., et al.
Publicado: (2021)

Influenza and respiratory syncytial virus (RSV) vaccines for infants: Safety, immunogenicity, and efficacy
por: Beeler, Judy A., et al.
Publicado: (2013)

The immunogenicity and safety of respiratory syncytial virus vaccines in development: A systematic review
por: Shan, Jing, et al.
Publicado: (2021)

Characterization of the humoral and cellular immunity induced by a recombinant BCG vaccine for the respiratory syncytial virus in healthy adults
por: Pacheco, Gaspar A., et al.
Publicado: (2023)

Detection of respiratory syncytial virus and rhinovirus in healthy infants
por: Hasegawa, Kohei, et al.
Publicado: (2015)

Structure-Based Design of Head-Only Fusion Glycoprotein Immunogens for Respiratory Syncytial Virus
por: Boyington, Jeffrey C., et al.
Publicado: (2016)

Dual Role of Respiratory Syncytial Virus Glycoprotein Fragment as a Mucosal Immunogen and Chemotactic Adjuvant
por: Kim, Sol, et al.
Publicado: (2012)

Refining the Balance of Attenuation and Immunogenicity of Respiratory Syncytial Virus by Targeted Codon Deoptimization of Virulence Genes
por: Meng, Jia, et al.
Publicado: (2014)

Immunization with recombinant rabies virus expressing Interleukin-18 exhibits enhanced immunogenicity and protection in mice
por: Gai, Weiwei, et al.
Publicado: (2017)

Safety and immunogenicity evaluation of recombinant BCG vaccine against respiratory syncytial virus in a randomized, double-blind, placebo-controlled phase I clinical trial
por: Abarca, Katia, et al.
Publicado: (2020)

End-of-study safety, immunogenicity, and efficacy of quadrivalent HPV (types 6, 11, 16, 18) recombinant vaccine in adult women 24–45 years of age
por: Castellsagué, X, et al.
Publicado: (2011)

Respiratory Syncytial Virus Hospitalizations in Healthy Preterm Infants: Systematic Review
por: Mauskopf, Josephine, et al.
Publicado: (2016)

Immunogenicity and Protective Efficacy of a Dual Subunit Vaccine Against Respiratory Syncytial Virus and Influenza Virus
por: Park, Min-Hee, et al.
Publicado: (2012)

Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B
por: Joyce, M. Gordon, et al.
Publicado: (2019)

Immunogenicity and safety of the HPV-16/18 AS04-adjuvanted vaccine in healthy Chinese girls and women aged 9 to 45 years: Results from 2 randomized controlled trials
por: Zhu, Fengcai, et al.
Publicado: (2014)

Respiratory Syncytial Virus
por: Fraire, Armando E., et al.
Publicado: (2013)

Respiratory syncytial virus
por: Ruuskanen, Olli, et al.
Publicado: (1993)

Respiratory syncytial virus
por: Munoz, Flor M., et al.
Publicado: (2020)

Safety and Immunogenicity of a ChAd155-Vectored Respiratory Syncytial Virus (RSV) Vaccine in Healthy RSV-Seropositive Children 12–23 Months of Age
por: Díez-Domingo, Javier, et al.
Publicado: (2022)

Respiratory syncytial virus in severe lower respiratory infections in previously healthy young Ethiopian infants
por: Weldetsadik, Abate Yeshidinber, et al.
Publicado: (2021)

Seroprevalence of human respiratory syncytial virus and human metapneumovirus in healthy population analyzed by recombinant fusion protein-based enzyme linked immunosorbent assay
por: Sastre, Patricia, et al.
Publicado: (2012)

Immunogenicity and Protective Capacity of a Virosomal Respiratory Syncytial Virus Vaccine Adjuvanted with Monophosphoryl Lipid A in Mice
por: Kamphuis, Tobias, et al.
Publicado: (2012)

Protective Efficacy and Immunogenicity of a Combinatory DNA Vaccine against Influenza A Virus and the Respiratory Syncytial Virus
por: Stab, Viktoria, et al.
Publicado: (2013)

Immunogenicity and safety of a respiratory syncytial virus fusion protein (RSV F) nanoparticle vaccine in older adults
por: Fries, Louis, et al.
Publicado: (2017)

Immunogenicity of an AS01-adjuvanted respiratory syncytial virus prefusion F (RSVPreF3) vaccine in animal models
por: Bouzya, Badiaa, et al.
Publicado: (2023)

Functional Features of the Respiratory Syncytial Virus G Protein
por: Anderson, Larry J., et al.
Publicado: (2021)

Safety and immunogenicity of human papillomavirus-16/18 AS04-adjuvanted vaccine in healthy Chinese females aged 15 to 45 years: a phase I trial
por: Zhu, Feng-Cai, et al.
Publicado: (2011)

Evaluation of the Safety and Immune Efficacy of Recombinant Human Respiratory Syncytial Virus Strain Long Live Attenuated Vaccine Candidates
por: Wang, Li-Nan, et al.
Publicado: (2021)

An Overview of Respiratory Syncytial Virus
por: Meng, Jia, et al.
Publicado: (2014)

Respiratory Syncytial Virus (RSV)
por: Walsh, Edward E., et al.
Publicado: (2015)

RIBAVIRIN AND RESPIRATORY SYNCYTIAL VIRUS
Publicado: (1986)

Bovine Respiratory Syncytial Virus
por: WELLEMANS, G.
Publicado: (1990)

An update on respiratory syncytial virus
por: Piralla, Antonio, et al.
Publicado: (2023)

Construction and immunogenicity of a recombinant fowlpox vaccine coexpressing S1 glycoprotein of infectious bronchitis virus and chicken IL-18
por: Chen, Hong-Ying, et al.
Publicado: (2010)

Alveolar macrophages and airway hyperresponsiveness associated with respiratory syncytial virus infection
por: Wang, Yuxin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4p7avlg9biu51d3ojhsjl705v2