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Multi-Omics Endotypes in ICU Sepsis-Induced Immunosuppression

It is evident that the admission of some patients with sepsis and septic shock to hospitals is occurring late in their illness, which has contributed to the increase in poor outcomes and high fatalities worldwide across age groups. The current diagnostic and monitoring procedure relies on an inaccur...

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Autores principales: Garduno, Alexis, Cusack, Rachael, Leone, Marc, Einav, Sharon, Martin-Loeches, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221354/
https://www.ncbi.nlm.nih.gov/pubmed/37317092
http://dx.doi.org/10.3390/microorganisms11051119
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author Garduno, Alexis
Cusack, Rachael
Leone, Marc
Einav, Sharon
Martin-Loeches, Ignacio
author_facet Garduno, Alexis
Cusack, Rachael
Leone, Marc
Einav, Sharon
Martin-Loeches, Ignacio
author_sort Garduno, Alexis
collection PubMed
description It is evident that the admission of some patients with sepsis and septic shock to hospitals is occurring late in their illness, which has contributed to the increase in poor outcomes and high fatalities worldwide across age groups. The current diagnostic and monitoring procedure relies on an inaccurate and often delayed identification by the clinician, who then decides the treatment upon interaction with the patient. Initiation of sepsis is accompanied by immune system paralysis following “cytokine storm”. The unique immunological response of each patient is important to define in terms of subtyping for therapy. The immune system becomes activated in sepsis to produce interleukins, and endothelial cells express higher levels of adhesion molecules. The proportions of circulating immune cells change, reducing regulatory cells and increasing memory cells and killer cells, having long-term effects on the phenotype of CD8 T cells, HLA-DR, and dysregulation of microRNA. The current narrative review seeks to highlight the potential application of multi-omics data integration and immunological profiling at the single-cell level to define endotypes in sepsis and septic shock. The review will consider the parallels and immunoregulatory axis between cancer and immunosuppression, sepsis-induced cardiomyopathy, and endothelial damage. Second, the added value of transcriptomic-driven endotypes will be assessed through inferring regulatory interactions in recent clinical trials and studies reporting gene modular features that inform continuous metrics measuring clinical response in ICU, which can support the use of immunomodulating agents.
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spelling pubmed-102213542023-05-28 Multi-Omics Endotypes in ICU Sepsis-Induced Immunosuppression Garduno, Alexis Cusack, Rachael Leone, Marc Einav, Sharon Martin-Loeches, Ignacio Microorganisms Review It is evident that the admission of some patients with sepsis and septic shock to hospitals is occurring late in their illness, which has contributed to the increase in poor outcomes and high fatalities worldwide across age groups. The current diagnostic and monitoring procedure relies on an inaccurate and often delayed identification by the clinician, who then decides the treatment upon interaction with the patient. Initiation of sepsis is accompanied by immune system paralysis following “cytokine storm”. The unique immunological response of each patient is important to define in terms of subtyping for therapy. The immune system becomes activated in sepsis to produce interleukins, and endothelial cells express higher levels of adhesion molecules. The proportions of circulating immune cells change, reducing regulatory cells and increasing memory cells and killer cells, having long-term effects on the phenotype of CD8 T cells, HLA-DR, and dysregulation of microRNA. The current narrative review seeks to highlight the potential application of multi-omics data integration and immunological profiling at the single-cell level to define endotypes in sepsis and septic shock. The review will consider the parallels and immunoregulatory axis between cancer and immunosuppression, sepsis-induced cardiomyopathy, and endothelial damage. Second, the added value of transcriptomic-driven endotypes will be assessed through inferring regulatory interactions in recent clinical trials and studies reporting gene modular features that inform continuous metrics measuring clinical response in ICU, which can support the use of immunomodulating agents. MDPI 2023-04-25 /pmc/articles/PMC10221354/ /pubmed/37317092 http://dx.doi.org/10.3390/microorganisms11051119 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Garduno, Alexis
Cusack, Rachael
Leone, Marc
Einav, Sharon
Martin-Loeches, Ignacio
Multi-Omics Endotypes in ICU Sepsis-Induced Immunosuppression
title Multi-Omics Endotypes in ICU Sepsis-Induced Immunosuppression
title_full Multi-Omics Endotypes in ICU Sepsis-Induced Immunosuppression
title_fullStr Multi-Omics Endotypes in ICU Sepsis-Induced Immunosuppression
title_full_unstemmed Multi-Omics Endotypes in ICU Sepsis-Induced Immunosuppression
title_short Multi-Omics Endotypes in ICU Sepsis-Induced Immunosuppression
title_sort multi-omics endotypes in icu sepsis-induced immunosuppression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221354/
https://www.ncbi.nlm.nih.gov/pubmed/37317092
http://dx.doi.org/10.3390/microorganisms11051119
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