Temsavir Modulates HIV-1 Envelope Conformation by Decreasing Its Proteolytic Cleavage

HIV-1 envelope glycoproteins (Envs) mediate viral entry and represent a target of choice for small molecule inhibitors. One of them, temsavir (BMS-626529) prevents the interaction of the host cell receptor CD4 with Env by binding the pocket under the β20–β21 loop of the Env subunit gp120. Along with...

Descripción completa

Detalles Bibliográficos
Autores principales: Boutin, Marianne, Medjahed, Halima, Nayrac, Manon, Lotke, Rishikesh, Gendron-Lepage, Gabrielle, Bourassa, Catherine, Sauter, Daniel, Richard, Jonathan, Finzi, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221371/
https://www.ncbi.nlm.nih.gov/pubmed/37243275
http://dx.doi.org/10.3390/v15051189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221371/
https://www.ncbi.nlm.nih.gov/pubmed/37243275
http://dx.doi.org/10.3390/v15051189

Ejemplares similares