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Temsavir Modulates HIV-1 Envelope Conformation by Decreasing Its Proteolytic Cleavage

HIV-1 envelope glycoproteins (Envs) mediate viral entry and represent a target of choice for small molecule inhibitors. One of them, temsavir (BMS-626529) prevents the interaction of the host cell receptor CD4 with Env by binding the pocket under the β20–β21 loop of the Env subunit gp120. Along with...

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Detalles Bibliográficos
Autores principales:	Boutin, Marianne, Medjahed, Halima, Nayrac, Manon, Lotke, Rishikesh, Gendron-Lepage, Gabrielle, Bourassa, Catherine, Sauter, Daniel, Richard, Jonathan, Finzi, Andrés
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221371/ https://www.ncbi.nlm.nih.gov/pubmed/37243275 http://dx.doi.org/10.3390/v15051189

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