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No Evidence That Circulating GLP-1 or PYY Are Associated with Increased Satiety during Low Energy Diet-Induced Weight Loss: Modelling Biomarkers of Appetite

Bariatric surgery and pharmacology treatments increase circulating glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), in turn promoting satiety and body weight (BW) loss. However, the utility of GLP-1 and PYY in predicting appetite response during dietary interventions remains unsubstantiated. Th...

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Autores principales: Lim, Jia Jiet, Liu, Yutong, Lu, Louise W., Sequeira, Ivana R., Poppitt, Sally D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221374/
https://www.ncbi.nlm.nih.gov/pubmed/37242282
http://dx.doi.org/10.3390/nu15102399
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author Lim, Jia Jiet
Liu, Yutong
Lu, Louise W.
Sequeira, Ivana R.
Poppitt, Sally D.
author_facet Lim, Jia Jiet
Liu, Yutong
Lu, Louise W.
Sequeira, Ivana R.
Poppitt, Sally D.
author_sort Lim, Jia Jiet
collection PubMed
description Bariatric surgery and pharmacology treatments increase circulating glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), in turn promoting satiety and body weight (BW) loss. However, the utility of GLP-1 and PYY in predicting appetite response during dietary interventions remains unsubstantiated. This study investigated whether the decrease in hunger observed following low energy diet (LED)-induced weight loss was associated with increased circulating ‘satiety peptides’, and/or associated changes in glucose, glucoregulatory peptides or amino acids (AAs). In total, 121 women with obesity underwent an 8-week LED intervention, of which 32 completed an appetite assessment via a preload challenge at both Week 0 and Week 8, and are reported here. Visual analogue scales (VAS) were administered to assess appetite-related responses, and blood samples were collected over 210 min post-preload. The area under the curve (AUC(0-210)), incremental AUC (iAUC(0-210)), and change from Week 0 to Week 8 (∆) were calculated. Multiple linear regression was used to test the association between VAS–appetite responses and blood biomarkers. Mean (±SEM) BW loss was 8.4 ± 0.5 kg (−8%). Unexpectedly, the decrease in ∆AUC(0-210) hunger was best associated with decreased ∆AUC(0-210) GLP-1, GIP, and valine (p < 0.05, all), and increased ∆AUC(0-210) glycine and proline (p < 0.05, both). The majority of associations remained significant after adjusting for BW and fat-free mass loss. There was no evidence that changes in circulating GLP-1 or PYY were predictive of changes in appetite-related responses. The modelling suggested that other putative blood biomarkers of appetite, such as AAs, should be further investigated in future larger longitudinal dietary studies.
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spelling pubmed-102213742023-05-28 No Evidence That Circulating GLP-1 or PYY Are Associated with Increased Satiety during Low Energy Diet-Induced Weight Loss: Modelling Biomarkers of Appetite Lim, Jia Jiet Liu, Yutong Lu, Louise W. Sequeira, Ivana R. Poppitt, Sally D. Nutrients Article Bariatric surgery and pharmacology treatments increase circulating glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), in turn promoting satiety and body weight (BW) loss. However, the utility of GLP-1 and PYY in predicting appetite response during dietary interventions remains unsubstantiated. This study investigated whether the decrease in hunger observed following low energy diet (LED)-induced weight loss was associated with increased circulating ‘satiety peptides’, and/or associated changes in glucose, glucoregulatory peptides or amino acids (AAs). In total, 121 women with obesity underwent an 8-week LED intervention, of which 32 completed an appetite assessment via a preload challenge at both Week 0 and Week 8, and are reported here. Visual analogue scales (VAS) were administered to assess appetite-related responses, and blood samples were collected over 210 min post-preload. The area under the curve (AUC(0-210)), incremental AUC (iAUC(0-210)), and change from Week 0 to Week 8 (∆) were calculated. Multiple linear regression was used to test the association between VAS–appetite responses and blood biomarkers. Mean (±SEM) BW loss was 8.4 ± 0.5 kg (−8%). Unexpectedly, the decrease in ∆AUC(0-210) hunger was best associated with decreased ∆AUC(0-210) GLP-1, GIP, and valine (p < 0.05, all), and increased ∆AUC(0-210) glycine and proline (p < 0.05, both). The majority of associations remained significant after adjusting for BW and fat-free mass loss. There was no evidence that changes in circulating GLP-1 or PYY were predictive of changes in appetite-related responses. The modelling suggested that other putative blood biomarkers of appetite, such as AAs, should be further investigated in future larger longitudinal dietary studies. MDPI 2023-05-20 /pmc/articles/PMC10221374/ /pubmed/37242282 http://dx.doi.org/10.3390/nu15102399 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lim, Jia Jiet
Liu, Yutong
Lu, Louise W.
Sequeira, Ivana R.
Poppitt, Sally D.
No Evidence That Circulating GLP-1 or PYY Are Associated with Increased Satiety during Low Energy Diet-Induced Weight Loss: Modelling Biomarkers of Appetite
title No Evidence That Circulating GLP-1 or PYY Are Associated with Increased Satiety during Low Energy Diet-Induced Weight Loss: Modelling Biomarkers of Appetite
title_full No Evidence That Circulating GLP-1 or PYY Are Associated with Increased Satiety during Low Energy Diet-Induced Weight Loss: Modelling Biomarkers of Appetite
title_fullStr No Evidence That Circulating GLP-1 or PYY Are Associated with Increased Satiety during Low Energy Diet-Induced Weight Loss: Modelling Biomarkers of Appetite
title_full_unstemmed No Evidence That Circulating GLP-1 or PYY Are Associated with Increased Satiety during Low Energy Diet-Induced Weight Loss: Modelling Biomarkers of Appetite
title_short No Evidence That Circulating GLP-1 or PYY Are Associated with Increased Satiety during Low Energy Diet-Induced Weight Loss: Modelling Biomarkers of Appetite
title_sort no evidence that circulating glp-1 or pyy are associated with increased satiety during low energy diet-induced weight loss: modelling biomarkers of appetite
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221374/
https://www.ncbi.nlm.nih.gov/pubmed/37242282
http://dx.doi.org/10.3390/nu15102399
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