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Electrospun Nanofibers for Dura Mater Regeneration: A Mini Review on Current Progress

Dural defects are a common problem in neurosurgical procedures and should be repaired to avoid complications such as cerebrospinal fluid leakage, brain swelling, epilepsy, intracranial infection, and so on. Various types of dural substitutes have been prepared and used for the treatment of dural def...

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Detalles Bibliográficos
Autores principales: Pant, Bishweshwar, Park, Mira, Kim, Allison A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221393/
https://www.ncbi.nlm.nih.gov/pubmed/37242589
http://dx.doi.org/10.3390/pharmaceutics15051347
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author Pant, Bishweshwar
Park, Mira
Kim, Allison A.
author_facet Pant, Bishweshwar
Park, Mira
Kim, Allison A.
author_sort Pant, Bishweshwar
collection PubMed
description Dural defects are a common problem in neurosurgical procedures and should be repaired to avoid complications such as cerebrospinal fluid leakage, brain swelling, epilepsy, intracranial infection, and so on. Various types of dural substitutes have been prepared and used for the treatment of dural defects. In recent years, electrospun nanofibers have been applied for various biomedical applications, including dural regeneration, due to their interesting properties such as a large surface area to volume ratio, porosity, superior mechanical properties, ease of surface modification, and, most importantly, similarity with the extracellular matrix (ECM). Despite continuous efforts, the development of suitable dura mater substrates has had limited success. This review summarizes the investigation and development of electrospun nanofibers with particular emphasis on dura mater regeneration. The objective of this mini-review article is to give readers a quick overview of the recent advances in electrospinning for dura mater repair.
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spelling pubmed-102213932023-05-28 Electrospun Nanofibers for Dura Mater Regeneration: A Mini Review on Current Progress Pant, Bishweshwar Park, Mira Kim, Allison A. Pharmaceutics Review Dural defects are a common problem in neurosurgical procedures and should be repaired to avoid complications such as cerebrospinal fluid leakage, brain swelling, epilepsy, intracranial infection, and so on. Various types of dural substitutes have been prepared and used for the treatment of dural defects. In recent years, electrospun nanofibers have been applied for various biomedical applications, including dural regeneration, due to their interesting properties such as a large surface area to volume ratio, porosity, superior mechanical properties, ease of surface modification, and, most importantly, similarity with the extracellular matrix (ECM). Despite continuous efforts, the development of suitable dura mater substrates has had limited success. This review summarizes the investigation and development of electrospun nanofibers with particular emphasis on dura mater regeneration. The objective of this mini-review article is to give readers a quick overview of the recent advances in electrospinning for dura mater repair. MDPI 2023-04-27 /pmc/articles/PMC10221393/ /pubmed/37242589 http://dx.doi.org/10.3390/pharmaceutics15051347 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pant, Bishweshwar
Park, Mira
Kim, Allison A.
Electrospun Nanofibers for Dura Mater Regeneration: A Mini Review on Current Progress
title Electrospun Nanofibers for Dura Mater Regeneration: A Mini Review on Current Progress
title_full Electrospun Nanofibers for Dura Mater Regeneration: A Mini Review on Current Progress
title_fullStr Electrospun Nanofibers for Dura Mater Regeneration: A Mini Review on Current Progress
title_full_unstemmed Electrospun Nanofibers for Dura Mater Regeneration: A Mini Review on Current Progress
title_short Electrospun Nanofibers for Dura Mater Regeneration: A Mini Review on Current Progress
title_sort electrospun nanofibers for dura mater regeneration: a mini review on current progress
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221393/
https://www.ncbi.nlm.nih.gov/pubmed/37242589
http://dx.doi.org/10.3390/pharmaceutics15051347
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