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Biocompatible Calcium Ion-Doped Magnesium Ferrite Nanoparticles as a New Family of Photothermal Therapeutic Materials for Cancer Treatment

Novel biocompatible and efficient photothermal (PT) therapeutic materials for cancer treatment have recently garnered significant attention, owing to their effective ablation of cancer cells, minimal invasiveness, quick recovery, and minimal damage to healthy cells. In this study, we designed and de...

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Autores principales: Manivasagan, Panchanathan, Ashokkumar, Sekar, Manohar, Ala, Joe, Ara, Han, Hyo-Won, Seo, Sun-Hwa, Thambi, Thavasyappan, Duong, Hai-Sang, Kaushik, Nagendra Kumar, Kim, Ki Hyeon, Choi, Eun Ha, Jang, Eue-Soon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221417/
https://www.ncbi.nlm.nih.gov/pubmed/37242798
http://dx.doi.org/10.3390/pharmaceutics15051555
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author Manivasagan, Panchanathan
Ashokkumar, Sekar
Manohar, Ala
Joe, Ara
Han, Hyo-Won
Seo, Sun-Hwa
Thambi, Thavasyappan
Duong, Hai-Sang
Kaushik, Nagendra Kumar
Kim, Ki Hyeon
Choi, Eun Ha
Jang, Eue-Soon
author_facet Manivasagan, Panchanathan
Ashokkumar, Sekar
Manohar, Ala
Joe, Ara
Han, Hyo-Won
Seo, Sun-Hwa
Thambi, Thavasyappan
Duong, Hai-Sang
Kaushik, Nagendra Kumar
Kim, Ki Hyeon
Choi, Eun Ha
Jang, Eue-Soon
author_sort Manivasagan, Panchanathan
collection PubMed
description Novel biocompatible and efficient photothermal (PT) therapeutic materials for cancer treatment have recently garnered significant attention, owing to their effective ablation of cancer cells, minimal invasiveness, quick recovery, and minimal damage to healthy cells. In this study, we designed and developed calcium ion-doped magnesium ferrite nanoparticles (Ca(2+)-doped MgFe(2)O(4) NPs) as novel and effective PT therapeutic materials for cancer treatment, owing to their good biocompatibility, biosafety, high near-infrared (NIR) absorption, easy localization, short treatment period, remote controllability, high efficiency, and high specificity. The studied Ca(2+)-doped MgFe(2)O(4) NPs exhibited a uniform spherical morphology with particle sizes of 14.24 ± 1.32 nm and a strong PT conversion efficiency (30.12%), making them promising for cancer photothermal therapy (PTT). In vitro experiments showed that Ca(2+)-doped MgFe(2)O(4) NPs had no significant cytotoxic effects on non-laser-irradiated MDA-MB-231 cells, confirming that Ca(2+)-doped MgFe(2)O(4) NPs exhibited high biocompatibility. More interestingly, Ca(2+)-doped MgFe(2)O(4) NPs exhibited superior cytotoxicity to laser-irradiated MDA-MB-231 cells, inducing significant cell death. Our study proposes novel, safe, high-efficiency, and biocompatible PT therapeutics for treating cancers, opening new vistas for the future development of cancer PTT.
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spelling pubmed-102214172023-05-28 Biocompatible Calcium Ion-Doped Magnesium Ferrite Nanoparticles as a New Family of Photothermal Therapeutic Materials for Cancer Treatment Manivasagan, Panchanathan Ashokkumar, Sekar Manohar, Ala Joe, Ara Han, Hyo-Won Seo, Sun-Hwa Thambi, Thavasyappan Duong, Hai-Sang Kaushik, Nagendra Kumar Kim, Ki Hyeon Choi, Eun Ha Jang, Eue-Soon Pharmaceutics Article Novel biocompatible and efficient photothermal (PT) therapeutic materials for cancer treatment have recently garnered significant attention, owing to their effective ablation of cancer cells, minimal invasiveness, quick recovery, and minimal damage to healthy cells. In this study, we designed and developed calcium ion-doped magnesium ferrite nanoparticles (Ca(2+)-doped MgFe(2)O(4) NPs) as novel and effective PT therapeutic materials for cancer treatment, owing to their good biocompatibility, biosafety, high near-infrared (NIR) absorption, easy localization, short treatment period, remote controllability, high efficiency, and high specificity. The studied Ca(2+)-doped MgFe(2)O(4) NPs exhibited a uniform spherical morphology with particle sizes of 14.24 ± 1.32 nm and a strong PT conversion efficiency (30.12%), making them promising for cancer photothermal therapy (PTT). In vitro experiments showed that Ca(2+)-doped MgFe(2)O(4) NPs had no significant cytotoxic effects on non-laser-irradiated MDA-MB-231 cells, confirming that Ca(2+)-doped MgFe(2)O(4) NPs exhibited high biocompatibility. More interestingly, Ca(2+)-doped MgFe(2)O(4) NPs exhibited superior cytotoxicity to laser-irradiated MDA-MB-231 cells, inducing significant cell death. Our study proposes novel, safe, high-efficiency, and biocompatible PT therapeutics for treating cancers, opening new vistas for the future development of cancer PTT. MDPI 2023-05-21 /pmc/articles/PMC10221417/ /pubmed/37242798 http://dx.doi.org/10.3390/pharmaceutics15051555 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Manivasagan, Panchanathan
Ashokkumar, Sekar
Manohar, Ala
Joe, Ara
Han, Hyo-Won
Seo, Sun-Hwa
Thambi, Thavasyappan
Duong, Hai-Sang
Kaushik, Nagendra Kumar
Kim, Ki Hyeon
Choi, Eun Ha
Jang, Eue-Soon
Biocompatible Calcium Ion-Doped Magnesium Ferrite Nanoparticles as a New Family of Photothermal Therapeutic Materials for Cancer Treatment
title Biocompatible Calcium Ion-Doped Magnesium Ferrite Nanoparticles as a New Family of Photothermal Therapeutic Materials for Cancer Treatment
title_full Biocompatible Calcium Ion-Doped Magnesium Ferrite Nanoparticles as a New Family of Photothermal Therapeutic Materials for Cancer Treatment
title_fullStr Biocompatible Calcium Ion-Doped Magnesium Ferrite Nanoparticles as a New Family of Photothermal Therapeutic Materials for Cancer Treatment
title_full_unstemmed Biocompatible Calcium Ion-Doped Magnesium Ferrite Nanoparticles as a New Family of Photothermal Therapeutic Materials for Cancer Treatment
title_short Biocompatible Calcium Ion-Doped Magnesium Ferrite Nanoparticles as a New Family of Photothermal Therapeutic Materials for Cancer Treatment
title_sort biocompatible calcium ion-doped magnesium ferrite nanoparticles as a new family of photothermal therapeutic materials for cancer treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221417/
https://www.ncbi.nlm.nih.gov/pubmed/37242798
http://dx.doi.org/10.3390/pharmaceutics15051555
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