Cargando…

Local Anesthetic Systemic Toxicity Following Inadvertent Intravenous Levobupivacaine Infusion in Infants: A Case Report

Background and objectives: Local anesthetic systemic toxicity (LAST) in children is extremely rare, occurring at an estimated rate of 0.76 cases per 10,000 procedures. However, among reported cases of LAST in the pediatric population, infants and neonates represent approximately 54% of reported LAST...

Descripción completa

Detalles Bibliográficos
Autores principales: Jermolajevaite, Justina, Razlevice, Ilona, Gurskis, Vaidotas, Grinkeviciute, Dovile Evalda, Lukosiene, Laura, Macas, Andrius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221613/
https://www.ncbi.nlm.nih.gov/pubmed/37241213
http://dx.doi.org/10.3390/medicina59050981
_version_ 1785049498259554304
author Jermolajevaite, Justina
Razlevice, Ilona
Gurskis, Vaidotas
Grinkeviciute, Dovile Evalda
Lukosiene, Laura
Macas, Andrius
author_facet Jermolajevaite, Justina
Razlevice, Ilona
Gurskis, Vaidotas
Grinkeviciute, Dovile Evalda
Lukosiene, Laura
Macas, Andrius
author_sort Jermolajevaite, Justina
collection PubMed
description Background and objectives: Local anesthetic systemic toxicity (LAST) in children is extremely rare, occurring at an estimated rate of 0.76 cases per 10,000 procedures. However, among reported cases of LAST in the pediatric population, infants and neonates represent approximately 54% of reported LAST cases. We aim to present and discuss the clinical case of LAST with full clinical recovery due to accidental levobupivacaine intravenous infusion in a healthy 1.5-month-old patient, resulting in cardiac arrest necessitating resuscitation. Case presentation: A 4-kilogram, 1.5-month-old female infant, ASA I, presented to the hospital for elective herniorrhaphy surgery. Combined anesthesia was planned, involving general endotracheal and caudal anesthesia. After anesthesia induction, cardiovascular collapse was noticed, resulting in bradycardia and later cardiac arrest with EMD (Electromechanical Dissociation). It was noticed that during induction, levobupivacaine was accidentally infused intravenously. A local anesthetic was prepared for caudal anesthesia. LET (lipid emulsion therapy) was started immediately. Cardiopulmonary resuscitation was carried out according to the EMD algorithm, which lasted 12 min until spontaneous circulation was confirmed and the patient was transferred to the ICU. In ICU, the girl was extubated the second day, and the third day she was transferred to the regular pediatric unit. Finally, the patient was discharged home after a total of five days of hospitalization with full clinical recovery. A four-week follow-up has revealed that the patient recovered without any neurological or cardiac sequelae. Conclusions: The clinical presentation of LAST in children usually begins with cardiovascular symptoms because pediatric patients are already under general anesthesia when anesthetics are being used, as was the case in our case. Treatment and management of LAST involve cessation of local anesthetic infusion, stabilization of the airway, breathing, and hemodynamics, as well as lipid emulsion therapy. Early recognition of LAST as well as immediate CPR if needed and targeted treatment for LAST can lead to good outcomes.
format Online
Article
Text
id pubmed-10221613
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102216132023-05-28 Local Anesthetic Systemic Toxicity Following Inadvertent Intravenous Levobupivacaine Infusion in Infants: A Case Report Jermolajevaite, Justina Razlevice, Ilona Gurskis, Vaidotas Grinkeviciute, Dovile Evalda Lukosiene, Laura Macas, Andrius Medicina (Kaunas) Case Report Background and objectives: Local anesthetic systemic toxicity (LAST) in children is extremely rare, occurring at an estimated rate of 0.76 cases per 10,000 procedures. However, among reported cases of LAST in the pediatric population, infants and neonates represent approximately 54% of reported LAST cases. We aim to present and discuss the clinical case of LAST with full clinical recovery due to accidental levobupivacaine intravenous infusion in a healthy 1.5-month-old patient, resulting in cardiac arrest necessitating resuscitation. Case presentation: A 4-kilogram, 1.5-month-old female infant, ASA I, presented to the hospital for elective herniorrhaphy surgery. Combined anesthesia was planned, involving general endotracheal and caudal anesthesia. After anesthesia induction, cardiovascular collapse was noticed, resulting in bradycardia and later cardiac arrest with EMD (Electromechanical Dissociation). It was noticed that during induction, levobupivacaine was accidentally infused intravenously. A local anesthetic was prepared for caudal anesthesia. LET (lipid emulsion therapy) was started immediately. Cardiopulmonary resuscitation was carried out according to the EMD algorithm, which lasted 12 min until spontaneous circulation was confirmed and the patient was transferred to the ICU. In ICU, the girl was extubated the second day, and the third day she was transferred to the regular pediatric unit. Finally, the patient was discharged home after a total of five days of hospitalization with full clinical recovery. A four-week follow-up has revealed that the patient recovered without any neurological or cardiac sequelae. Conclusions: The clinical presentation of LAST in children usually begins with cardiovascular symptoms because pediatric patients are already under general anesthesia when anesthetics are being used, as was the case in our case. Treatment and management of LAST involve cessation of local anesthetic infusion, stabilization of the airway, breathing, and hemodynamics, as well as lipid emulsion therapy. Early recognition of LAST as well as immediate CPR if needed and targeted treatment for LAST can lead to good outcomes. MDPI 2023-05-19 /pmc/articles/PMC10221613/ /pubmed/37241213 http://dx.doi.org/10.3390/medicina59050981 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Jermolajevaite, Justina
Razlevice, Ilona
Gurskis, Vaidotas
Grinkeviciute, Dovile Evalda
Lukosiene, Laura
Macas, Andrius
Local Anesthetic Systemic Toxicity Following Inadvertent Intravenous Levobupivacaine Infusion in Infants: A Case Report
title Local Anesthetic Systemic Toxicity Following Inadvertent Intravenous Levobupivacaine Infusion in Infants: A Case Report
title_full Local Anesthetic Systemic Toxicity Following Inadvertent Intravenous Levobupivacaine Infusion in Infants: A Case Report
title_fullStr Local Anesthetic Systemic Toxicity Following Inadvertent Intravenous Levobupivacaine Infusion in Infants: A Case Report
title_full_unstemmed Local Anesthetic Systemic Toxicity Following Inadvertent Intravenous Levobupivacaine Infusion in Infants: A Case Report
title_short Local Anesthetic Systemic Toxicity Following Inadvertent Intravenous Levobupivacaine Infusion in Infants: A Case Report
title_sort local anesthetic systemic toxicity following inadvertent intravenous levobupivacaine infusion in infants: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221613/
https://www.ncbi.nlm.nih.gov/pubmed/37241213
http://dx.doi.org/10.3390/medicina59050981
work_keys_str_mv AT jermolajevaitejustina localanestheticsystemictoxicityfollowinginadvertentintravenouslevobupivacaineinfusionininfantsacasereport
AT razleviceilona localanestheticsystemictoxicityfollowinginadvertentintravenouslevobupivacaineinfusionininfantsacasereport
AT gurskisvaidotas localanestheticsystemictoxicityfollowinginadvertentintravenouslevobupivacaineinfusionininfantsacasereport
AT grinkeviciutedovileevalda localanestheticsystemictoxicityfollowinginadvertentintravenouslevobupivacaineinfusionininfantsacasereport
AT lukosienelaura localanestheticsystemictoxicityfollowinginadvertentintravenouslevobupivacaineinfusionininfantsacasereport
AT macasandrius localanestheticsystemictoxicityfollowinginadvertentintravenouslevobupivacaineinfusionininfantsacasereport