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Oxidative Cyclization at ortho-Position of Phenol: Improved Total Synthesis of 3-(Phenethylamino)demethyl(oxy)aaptamine

A shorter synthesis of the demethyl(oxy)aaptamine skeleton was developed via oxidative intramolecular cyclization of 1-(2-azidoethyl)-6-methoxyisoquinolin-7-ol followed by dehydrogenation with a hypervalent iodine reagent. This is the first example of oxidative cyclization at the ortho-position of p...

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Detalles Bibliográficos
Autores principales:	Nakatani, Yuki, Kimura, Risa, Kimata, Tomoyo, Kotoku, Naoyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221624/ https://www.ncbi.nlm.nih.gov/pubmed/37233505 http://dx.doi.org/10.3390/md21050311

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