Enhancement of Inhibitory Activity by Combining Allosteric Inhibitors Putatively Binding to Different Allosteric Sites on Cathepsin K

Background: Cathepsin K, which is involved in bone resorption, is a good target for treating osteoporosis, but no clinically approved medicine has been developed. Recently, allosteric inhibitors with high specificity and few side effects have been attracting attention for use in new medicines. Metho...

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Detalles Bibliográficos
Autores principales: Sato, Shun, Yamamoto, Kana, Ito, Moeno, Nishino, Katsutoshi, Otsuka, Takanao, Irie, Kazuhiro, Nagao, Masaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221639/
https://www.ncbi.nlm.nih.gov/pubmed/37241936
http://dx.doi.org/10.3390/molecules28104197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221639/
https://www.ncbi.nlm.nih.gov/pubmed/37241936
http://dx.doi.org/10.3390/molecules28104197

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