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Synthesis and Antimalarial Evaluation of Halogenated Analogues of Thiaplakortone A

The incorporation of bromine, iodine or fluorine into the tricyclic core structure of thiaplakortone A (1), a potent antimalarial marine natural product, is reported. Although yields were low, it was possible to synthesise a small nine-membered library using the previously synthesised Boc-protected...

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Detalles Bibliográficos
Autores principales: Egbewande, Folake A., Schwartz, Brett D., Duffy, Sandra, Avery, Vicky M., Davis, Rohan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221708/
https://www.ncbi.nlm.nih.gov/pubmed/37233511
http://dx.doi.org/10.3390/md21050317

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