The Roles of Extracellular Vesicles in the Progression of Renal Cell Carcinoma and Their Potential for Future Clinical Application

Renal cell carcinoma (RCC) is the most common type of kidney cancer and is thought to originate from renal tubular epithelial cells. Extracellular vesicles (EVs) are nanosized lipid bilayer vesicles that are secreted into extracellular spaces by nearly all cell types, including cancer cells and non-...

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Autores principales: Takeda, Masashi, Akamatsu, Shusuke, Kita, Yuki, Goto, Takayuki, Kobayashi, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221968/
https://www.ncbi.nlm.nih.gov/pubmed/37242027
http://dx.doi.org/10.3390/nano13101611
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author Takeda, Masashi
Akamatsu, Shusuke
Kita, Yuki
Goto, Takayuki
Kobayashi, Takashi
author_facet Takeda, Masashi
Akamatsu, Shusuke
Kita, Yuki
Goto, Takayuki
Kobayashi, Takashi
author_sort Takeda, Masashi
collection PubMed
description Renal cell carcinoma (RCC) is the most common type of kidney cancer and is thought to originate from renal tubular epithelial cells. Extracellular vesicles (EVs) are nanosized lipid bilayer vesicles that are secreted into extracellular spaces by nearly all cell types, including cancer cells and non-cancerous cells. EVs are involved in multiple steps of RCC progression, such as local invasion, host immune modulation, drug resistance, and metastasis. Therefore, EVs secreted from RCC are attracting rapidly increasing attention from researchers. In this review, we highlight the mechanism by which RCC-derived EVs lead to disease progression as well as the potential and challenges related to the clinical implications of EV-based diagnostics and therapeutics.
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spelling pubmed-102219682023-05-28 The Roles of Extracellular Vesicles in the Progression of Renal Cell Carcinoma and Their Potential for Future Clinical Application Takeda, Masashi Akamatsu, Shusuke Kita, Yuki Goto, Takayuki Kobayashi, Takashi Nanomaterials (Basel) Review Renal cell carcinoma (RCC) is the most common type of kidney cancer and is thought to originate from renal tubular epithelial cells. Extracellular vesicles (EVs) are nanosized lipid bilayer vesicles that are secreted into extracellular spaces by nearly all cell types, including cancer cells and non-cancerous cells. EVs are involved in multiple steps of RCC progression, such as local invasion, host immune modulation, drug resistance, and metastasis. Therefore, EVs secreted from RCC are attracting rapidly increasing attention from researchers. In this review, we highlight the mechanism by which RCC-derived EVs lead to disease progression as well as the potential and challenges related to the clinical implications of EV-based diagnostics and therapeutics. MDPI 2023-05-11 /pmc/articles/PMC10221968/ /pubmed/37242027 http://dx.doi.org/10.3390/nano13101611 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Takeda, Masashi
Akamatsu, Shusuke
Kita, Yuki
Goto, Takayuki
Kobayashi, Takashi
The Roles of Extracellular Vesicles in the Progression of Renal Cell Carcinoma and Their Potential for Future Clinical Application
title The Roles of Extracellular Vesicles in the Progression of Renal Cell Carcinoma and Their Potential for Future Clinical Application
title_full The Roles of Extracellular Vesicles in the Progression of Renal Cell Carcinoma and Their Potential for Future Clinical Application
title_fullStr The Roles of Extracellular Vesicles in the Progression of Renal Cell Carcinoma and Their Potential for Future Clinical Application
title_full_unstemmed The Roles of Extracellular Vesicles in the Progression of Renal Cell Carcinoma and Their Potential for Future Clinical Application
title_short The Roles of Extracellular Vesicles in the Progression of Renal Cell Carcinoma and Their Potential for Future Clinical Application
title_sort roles of extracellular vesicles in the progression of renal cell carcinoma and their potential for future clinical application
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221968/
https://www.ncbi.nlm.nih.gov/pubmed/37242027
http://dx.doi.org/10.3390/nano13101611
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