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Risk Factors and the Impact of Multidrug-Resistant Bacteria on Community-Acquired Urinary Sepsis

Risk factors for multidrug-resistant bacteria (MDRB) in nosocomial urinary tract infection (UTI) have been widely studied. However, these risk factors have not been analyzed in community-acquired urinary sepsis (US), nor have its outcomes been studied. The aim of our study is to determine risk facto...

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Autores principales: Madrazo, Manuel, López-Cruz, Ian, Piles, Laura, Viñola, Sofía, Alberola, Juan, Eiros, José María, Artero, Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221993/
https://www.ncbi.nlm.nih.gov/pubmed/37317252
http://dx.doi.org/10.3390/microorganisms11051278
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author Madrazo, Manuel
López-Cruz, Ian
Piles, Laura
Viñola, Sofía
Alberola, Juan
Eiros, José María
Artero, Arturo
author_facet Madrazo, Manuel
López-Cruz, Ian
Piles, Laura
Viñola, Sofía
Alberola, Juan
Eiros, José María
Artero, Arturo
author_sort Madrazo, Manuel
collection PubMed
description Risk factors for multidrug-resistant bacteria (MDRB) in nosocomial urinary tract infection (UTI) have been widely studied. However, these risk factors have not been analyzed in community-acquired urinary sepsis (US), nor have its outcomes been studied. The aim of our study is to determine risk factors for MDRB in community-acquired US and its influence on outcomes. Prospective observational study of patients with community-acquired US admitted to a university hospital. We compared epidemiological and clinical variables and outcomes of US due to MDRB and non-MDRB. Independent risk factors for MDRB were analyzed using logistic regression. A total of 193 patients were included, 33.7% of them with US due to MDRB. The median age of patients was 82 years. Hospital mortality was 17.6%, with no difference between the MDRB and non-MDRB groups. The length of hospital stay was 5 (4–8) days, with a non-significant tendency to longer hospital stays in the MDRB group (6 (4–10) vs. 5 (4–8) days, p = 0.051). Healthcare-associated US was found to be an independent risk factor for MDR bacteria by multivariate analysis. In conclusion, the impact of MDR bacteria on the outcomes of community-acquired urinary sepsis was mild. Healthcare-associated US was an independent risk factor for MDR bacteria.
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spelling pubmed-102219932023-05-28 Risk Factors and the Impact of Multidrug-Resistant Bacteria on Community-Acquired Urinary Sepsis Madrazo, Manuel López-Cruz, Ian Piles, Laura Viñola, Sofía Alberola, Juan Eiros, José María Artero, Arturo Microorganisms Article Risk factors for multidrug-resistant bacteria (MDRB) in nosocomial urinary tract infection (UTI) have been widely studied. However, these risk factors have not been analyzed in community-acquired urinary sepsis (US), nor have its outcomes been studied. The aim of our study is to determine risk factors for MDRB in community-acquired US and its influence on outcomes. Prospective observational study of patients with community-acquired US admitted to a university hospital. We compared epidemiological and clinical variables and outcomes of US due to MDRB and non-MDRB. Independent risk factors for MDRB were analyzed using logistic regression. A total of 193 patients were included, 33.7% of them with US due to MDRB. The median age of patients was 82 years. Hospital mortality was 17.6%, with no difference between the MDRB and non-MDRB groups. The length of hospital stay was 5 (4–8) days, with a non-significant tendency to longer hospital stays in the MDRB group (6 (4–10) vs. 5 (4–8) days, p = 0.051). Healthcare-associated US was found to be an independent risk factor for MDR bacteria by multivariate analysis. In conclusion, the impact of MDR bacteria on the outcomes of community-acquired urinary sepsis was mild. Healthcare-associated US was an independent risk factor for MDR bacteria. MDPI 2023-05-13 /pmc/articles/PMC10221993/ /pubmed/37317252 http://dx.doi.org/10.3390/microorganisms11051278 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Madrazo, Manuel
López-Cruz, Ian
Piles, Laura
Viñola, Sofía
Alberola, Juan
Eiros, José María
Artero, Arturo
Risk Factors and the Impact of Multidrug-Resistant Bacteria on Community-Acquired Urinary Sepsis
title Risk Factors and the Impact of Multidrug-Resistant Bacteria on Community-Acquired Urinary Sepsis
title_full Risk Factors and the Impact of Multidrug-Resistant Bacteria on Community-Acquired Urinary Sepsis
title_fullStr Risk Factors and the Impact of Multidrug-Resistant Bacteria on Community-Acquired Urinary Sepsis
title_full_unstemmed Risk Factors and the Impact of Multidrug-Resistant Bacteria on Community-Acquired Urinary Sepsis
title_short Risk Factors and the Impact of Multidrug-Resistant Bacteria on Community-Acquired Urinary Sepsis
title_sort risk factors and the impact of multidrug-resistant bacteria on community-acquired urinary sepsis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221993/
https://www.ncbi.nlm.nih.gov/pubmed/37317252
http://dx.doi.org/10.3390/microorganisms11051278
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