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Risk Factors and the Impact of Multidrug-Resistant Bacteria on Community-Acquired Urinary Sepsis
Risk factors for multidrug-resistant bacteria (MDRB) in nosocomial urinary tract infection (UTI) have been widely studied. However, these risk factors have not been analyzed in community-acquired urinary sepsis (US), nor have its outcomes been studied. The aim of our study is to determine risk facto...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221993/ https://www.ncbi.nlm.nih.gov/pubmed/37317252 http://dx.doi.org/10.3390/microorganisms11051278 |
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author | Madrazo, Manuel López-Cruz, Ian Piles, Laura Viñola, Sofía Alberola, Juan Eiros, José María Artero, Arturo |
author_facet | Madrazo, Manuel López-Cruz, Ian Piles, Laura Viñola, Sofía Alberola, Juan Eiros, José María Artero, Arturo |
author_sort | Madrazo, Manuel |
collection | PubMed |
description | Risk factors for multidrug-resistant bacteria (MDRB) in nosocomial urinary tract infection (UTI) have been widely studied. However, these risk factors have not been analyzed in community-acquired urinary sepsis (US), nor have its outcomes been studied. The aim of our study is to determine risk factors for MDRB in community-acquired US and its influence on outcomes. Prospective observational study of patients with community-acquired US admitted to a university hospital. We compared epidemiological and clinical variables and outcomes of US due to MDRB and non-MDRB. Independent risk factors for MDRB were analyzed using logistic regression. A total of 193 patients were included, 33.7% of them with US due to MDRB. The median age of patients was 82 years. Hospital mortality was 17.6%, with no difference between the MDRB and non-MDRB groups. The length of hospital stay was 5 (4–8) days, with a non-significant tendency to longer hospital stays in the MDRB group (6 (4–10) vs. 5 (4–8) days, p = 0.051). Healthcare-associated US was found to be an independent risk factor for MDR bacteria by multivariate analysis. In conclusion, the impact of MDR bacteria on the outcomes of community-acquired urinary sepsis was mild. Healthcare-associated US was an independent risk factor for MDR bacteria. |
format | Online Article Text |
id | pubmed-10221993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102219932023-05-28 Risk Factors and the Impact of Multidrug-Resistant Bacteria on Community-Acquired Urinary Sepsis Madrazo, Manuel López-Cruz, Ian Piles, Laura Viñola, Sofía Alberola, Juan Eiros, José María Artero, Arturo Microorganisms Article Risk factors for multidrug-resistant bacteria (MDRB) in nosocomial urinary tract infection (UTI) have been widely studied. However, these risk factors have not been analyzed in community-acquired urinary sepsis (US), nor have its outcomes been studied. The aim of our study is to determine risk factors for MDRB in community-acquired US and its influence on outcomes. Prospective observational study of patients with community-acquired US admitted to a university hospital. We compared epidemiological and clinical variables and outcomes of US due to MDRB and non-MDRB. Independent risk factors for MDRB were analyzed using logistic regression. A total of 193 patients were included, 33.7% of them with US due to MDRB. The median age of patients was 82 years. Hospital mortality was 17.6%, with no difference between the MDRB and non-MDRB groups. The length of hospital stay was 5 (4–8) days, with a non-significant tendency to longer hospital stays in the MDRB group (6 (4–10) vs. 5 (4–8) days, p = 0.051). Healthcare-associated US was found to be an independent risk factor for MDR bacteria by multivariate analysis. In conclusion, the impact of MDR bacteria on the outcomes of community-acquired urinary sepsis was mild. Healthcare-associated US was an independent risk factor for MDR bacteria. MDPI 2023-05-13 /pmc/articles/PMC10221993/ /pubmed/37317252 http://dx.doi.org/10.3390/microorganisms11051278 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Madrazo, Manuel López-Cruz, Ian Piles, Laura Viñola, Sofía Alberola, Juan Eiros, José María Artero, Arturo Risk Factors and the Impact of Multidrug-Resistant Bacteria on Community-Acquired Urinary Sepsis |
title | Risk Factors and the Impact of Multidrug-Resistant Bacteria on Community-Acquired Urinary Sepsis |
title_full | Risk Factors and the Impact of Multidrug-Resistant Bacteria on Community-Acquired Urinary Sepsis |
title_fullStr | Risk Factors and the Impact of Multidrug-Resistant Bacteria on Community-Acquired Urinary Sepsis |
title_full_unstemmed | Risk Factors and the Impact of Multidrug-Resistant Bacteria on Community-Acquired Urinary Sepsis |
title_short | Risk Factors and the Impact of Multidrug-Resistant Bacteria on Community-Acquired Urinary Sepsis |
title_sort | risk factors and the impact of multidrug-resistant bacteria on community-acquired urinary sepsis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221993/ https://www.ncbi.nlm.nih.gov/pubmed/37317252 http://dx.doi.org/10.3390/microorganisms11051278 |
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