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Recent Progress in the Rational Design of Biothiol-Responsive Fluorescent Probes
Biothiols such as cysteine, homocysteine, and glutathione play significant roles in important biological activities, and their abnormal concentrations have been found to be closely associated with certain diseases, making their detection a critical task. To this end, fluorescent probes have become i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222014/ https://www.ncbi.nlm.nih.gov/pubmed/37241992 http://dx.doi.org/10.3390/molecules28104252 |
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author | Xie, Wenzhi Jiang, Jinyu Shu, Dunji Zhang, Yanjun Yang, Sheng Zhang, Kai |
author_facet | Xie, Wenzhi Jiang, Jinyu Shu, Dunji Zhang, Yanjun Yang, Sheng Zhang, Kai |
author_sort | Xie, Wenzhi |
collection | PubMed |
description | Biothiols such as cysteine, homocysteine, and glutathione play significant roles in important biological activities, and their abnormal concentrations have been found to be closely associated with certain diseases, making their detection a critical task. To this end, fluorescent probes have become increasingly popular due to their numerous advantages, including easy handling, desirable spatiotemporal resolution, high sensitivity, fast response, and favorable biocompatibility. As a result, intensive research has been conducted to create fluorescent probes for the detection and imaging of biothiols. This brief review summarizes recent advances in the field of biothiol-responsive fluorescent probes, with an emphasis on rational probe design, including the reaction mechanism, discriminating detection, reversible detection, and specific detection. Furthermore, the challenges and prospects of fluorescence probes for biothiols are also outlined. |
format | Online Article Text |
id | pubmed-10222014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102220142023-05-28 Recent Progress in the Rational Design of Biothiol-Responsive Fluorescent Probes Xie, Wenzhi Jiang, Jinyu Shu, Dunji Zhang, Yanjun Yang, Sheng Zhang, Kai Molecules Review Biothiols such as cysteine, homocysteine, and glutathione play significant roles in important biological activities, and their abnormal concentrations have been found to be closely associated with certain diseases, making their detection a critical task. To this end, fluorescent probes have become increasingly popular due to their numerous advantages, including easy handling, desirable spatiotemporal resolution, high sensitivity, fast response, and favorable biocompatibility. As a result, intensive research has been conducted to create fluorescent probes for the detection and imaging of biothiols. This brief review summarizes recent advances in the field of biothiol-responsive fluorescent probes, with an emphasis on rational probe design, including the reaction mechanism, discriminating detection, reversible detection, and specific detection. Furthermore, the challenges and prospects of fluorescence probes for biothiols are also outlined. MDPI 2023-05-22 /pmc/articles/PMC10222014/ /pubmed/37241992 http://dx.doi.org/10.3390/molecules28104252 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Xie, Wenzhi Jiang, Jinyu Shu, Dunji Zhang, Yanjun Yang, Sheng Zhang, Kai Recent Progress in the Rational Design of Biothiol-Responsive Fluorescent Probes |
title | Recent Progress in the Rational Design of Biothiol-Responsive Fluorescent Probes |
title_full | Recent Progress in the Rational Design of Biothiol-Responsive Fluorescent Probes |
title_fullStr | Recent Progress in the Rational Design of Biothiol-Responsive Fluorescent Probes |
title_full_unstemmed | Recent Progress in the Rational Design of Biothiol-Responsive Fluorescent Probes |
title_short | Recent Progress in the Rational Design of Biothiol-Responsive Fluorescent Probes |
title_sort | recent progress in the rational design of biothiol-responsive fluorescent probes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222014/ https://www.ncbi.nlm.nih.gov/pubmed/37241992 http://dx.doi.org/10.3390/molecules28104252 |
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