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Genetic Characterization and Evolution of Porcine Deltacoronavirus Isolated in the Republic of Korea in 2022
Porcine deltacoronavirus (PDCoV) is an emerging coronavirus that causes diarrhea in nursing piglets. Since its first outbreak in the United States in 2014, this novel porcine coronavirus has been detected worldwide, including in Korea. However, no PDCoV case has been reported since the last report i...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222072/ https://www.ncbi.nlm.nih.gov/pubmed/37242356 http://dx.doi.org/10.3390/pathogens12050686 |
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author | Kim, Hye-Ryung Park, Jonghyun Lee, Kyoung-Ki Jeoung, Hye-Young Lyoo, Young S. Park, Seung-Chun Park, Choi-Kyu |
author_facet | Kim, Hye-Ryung Park, Jonghyun Lee, Kyoung-Ki Jeoung, Hye-Young Lyoo, Young S. Park, Seung-Chun Park, Choi-Kyu |
author_sort | Kim, Hye-Ryung |
collection | PubMed |
description | Porcine deltacoronavirus (PDCoV) is an emerging coronavirus that causes diarrhea in nursing piglets. Since its first outbreak in the United States in 2014, this novel porcine coronavirus has been detected worldwide, including in Korea. However, no PDCoV case has been reported since the last report in 2016 in Korea. In June 2022, the Korean PDCoV strain KPDCoV-2201 was detected on a farm where sows and piglets had black tarry and watery diarrhea, respectively. We isolated the KPDCoV-2201 strain from the intestinal samples of piglets and sequenced the viral genome. Genetically, the full-length genome and spike gene of KPDCoV-2201 shared 96.9–99.2% and 95.8–98.8% nucleotide identity with other global PDCoV strains, respectively. Phylogenetic analysis suggested that KPDCoV-2201 belongs to G1b. Notably, the molecular evolutionary analysis indicated that KPDCoV-2201 evolved from a clade different from that of previously reported Korean PDCoV strains and is closely related to the emergent Peruvian and Taiwanese PDCoV strains. Furthermore, KPDCoV-2201 had one unique and two Taiwanese strain-like amino acid substitutions in the receptor-binding domain of the S1 region. Our findings suggest the possibility of transboundary transmission of the virus and expand our knowledge about the genetic diversity and evolution of PDCoV in Korea. |
format | Online Article Text |
id | pubmed-10222072 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102220722023-05-28 Genetic Characterization and Evolution of Porcine Deltacoronavirus Isolated in the Republic of Korea in 2022 Kim, Hye-Ryung Park, Jonghyun Lee, Kyoung-Ki Jeoung, Hye-Young Lyoo, Young S. Park, Seung-Chun Park, Choi-Kyu Pathogens Communication Porcine deltacoronavirus (PDCoV) is an emerging coronavirus that causes diarrhea in nursing piglets. Since its first outbreak in the United States in 2014, this novel porcine coronavirus has been detected worldwide, including in Korea. However, no PDCoV case has been reported since the last report in 2016 in Korea. In June 2022, the Korean PDCoV strain KPDCoV-2201 was detected on a farm where sows and piglets had black tarry and watery diarrhea, respectively. We isolated the KPDCoV-2201 strain from the intestinal samples of piglets and sequenced the viral genome. Genetically, the full-length genome and spike gene of KPDCoV-2201 shared 96.9–99.2% and 95.8–98.8% nucleotide identity with other global PDCoV strains, respectively. Phylogenetic analysis suggested that KPDCoV-2201 belongs to G1b. Notably, the molecular evolutionary analysis indicated that KPDCoV-2201 evolved from a clade different from that of previously reported Korean PDCoV strains and is closely related to the emergent Peruvian and Taiwanese PDCoV strains. Furthermore, KPDCoV-2201 had one unique and two Taiwanese strain-like amino acid substitutions in the receptor-binding domain of the S1 region. Our findings suggest the possibility of transboundary transmission of the virus and expand our knowledge about the genetic diversity and evolution of PDCoV in Korea. MDPI 2023-05-07 /pmc/articles/PMC10222072/ /pubmed/37242356 http://dx.doi.org/10.3390/pathogens12050686 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Kim, Hye-Ryung Park, Jonghyun Lee, Kyoung-Ki Jeoung, Hye-Young Lyoo, Young S. Park, Seung-Chun Park, Choi-Kyu Genetic Characterization and Evolution of Porcine Deltacoronavirus Isolated in the Republic of Korea in 2022 |
title | Genetic Characterization and Evolution of Porcine Deltacoronavirus Isolated in the Republic of Korea in 2022 |
title_full | Genetic Characterization and Evolution of Porcine Deltacoronavirus Isolated in the Republic of Korea in 2022 |
title_fullStr | Genetic Characterization and Evolution of Porcine Deltacoronavirus Isolated in the Republic of Korea in 2022 |
title_full_unstemmed | Genetic Characterization and Evolution of Porcine Deltacoronavirus Isolated in the Republic of Korea in 2022 |
title_short | Genetic Characterization and Evolution of Porcine Deltacoronavirus Isolated in the Republic of Korea in 2022 |
title_sort | genetic characterization and evolution of porcine deltacoronavirus isolated in the republic of korea in 2022 |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222072/ https://www.ncbi.nlm.nih.gov/pubmed/37242356 http://dx.doi.org/10.3390/pathogens12050686 |
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