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Early-Life Skin Microbial Biomarkers for Eczema Phenotypes in Chinese Toddlers
Eczema is a common inflammatory skin disorder during infancy. Evidence has shown that skin-microbiome fluctuations may precede eczema development, but their predictive value for eczema phenotypes remains unknown. We aimed to investigate the early-life evolution of the skin microbiome and its tempora...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222142/ https://www.ncbi.nlm.nih.gov/pubmed/37242367 http://dx.doi.org/10.3390/pathogens12050697 |
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author | Chen, Yehao Song, Yuping Chen, Zigui Yau, Jennifer Wing Ki Chan, Kate Ching Ching Leung, Agnes Sze Yin Chan, Oi Man Yeung, Apple Chung Man Yuen, Connie Lai Yuk Chan, Paul Kay Sheung Tam, Wing Hung Leung, Ting Fan |
author_facet | Chen, Yehao Song, Yuping Chen, Zigui Yau, Jennifer Wing Ki Chan, Kate Ching Ching Leung, Agnes Sze Yin Chan, Oi Man Yeung, Apple Chung Man Yuen, Connie Lai Yuk Chan, Paul Kay Sheung Tam, Wing Hung Leung, Ting Fan |
author_sort | Chen, Yehao |
collection | PubMed |
description | Eczema is a common inflammatory skin disorder during infancy. Evidence has shown that skin-microbiome fluctuations may precede eczema development, but their predictive value for eczema phenotypes remains unknown. We aimed to investigate the early-life evolution of the skin microbiome and its temporal associations with different pairs of eczema phenotypes (transient versus persistent, atopic versus non-atopic) in Chinese children. We followed 119 term Chinese infants from birth to 24 months old within a Hong Kong birth cohort. The skin microbes at the left antecubital fossa were serially sampled by flocked swabs at 1, 6, and 12 months for bacterial 16S rRNA gene sequencing. The atopic sensitization at 12 months was strongly associated with eczema persisting to 24 months (odds ratio 4.95, 95% confidence interval 1.29–19.01). Compared with those with non-atopic eczema, the children with atopic eczema had reduced alpha diversity at 12 months (p < 0.001) and transiently higher abundance of the genus Janibacter at 6 months (p < 0.001). Our findings suggest that atopic sensitization at 12 months may predict persistent eczema by 24 months, and atopic eczema at 12 months is associated with unique skin microbiome profiles at 6 and 12 months. Non-invasive skin-microbiome profiling may have predictive value for atopic eczema. |
format | Online Article Text |
id | pubmed-10222142 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102221422023-05-28 Early-Life Skin Microbial Biomarkers for Eczema Phenotypes in Chinese Toddlers Chen, Yehao Song, Yuping Chen, Zigui Yau, Jennifer Wing Ki Chan, Kate Ching Ching Leung, Agnes Sze Yin Chan, Oi Man Yeung, Apple Chung Man Yuen, Connie Lai Yuk Chan, Paul Kay Sheung Tam, Wing Hung Leung, Ting Fan Pathogens Article Eczema is a common inflammatory skin disorder during infancy. Evidence has shown that skin-microbiome fluctuations may precede eczema development, but their predictive value for eczema phenotypes remains unknown. We aimed to investigate the early-life evolution of the skin microbiome and its temporal associations with different pairs of eczema phenotypes (transient versus persistent, atopic versus non-atopic) in Chinese children. We followed 119 term Chinese infants from birth to 24 months old within a Hong Kong birth cohort. The skin microbes at the left antecubital fossa were serially sampled by flocked swabs at 1, 6, and 12 months for bacterial 16S rRNA gene sequencing. The atopic sensitization at 12 months was strongly associated with eczema persisting to 24 months (odds ratio 4.95, 95% confidence interval 1.29–19.01). Compared with those with non-atopic eczema, the children with atopic eczema had reduced alpha diversity at 12 months (p < 0.001) and transiently higher abundance of the genus Janibacter at 6 months (p < 0.001). Our findings suggest that atopic sensitization at 12 months may predict persistent eczema by 24 months, and atopic eczema at 12 months is associated with unique skin microbiome profiles at 6 and 12 months. Non-invasive skin-microbiome profiling may have predictive value for atopic eczema. MDPI 2023-05-11 /pmc/articles/PMC10222142/ /pubmed/37242367 http://dx.doi.org/10.3390/pathogens12050697 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chen, Yehao Song, Yuping Chen, Zigui Yau, Jennifer Wing Ki Chan, Kate Ching Ching Leung, Agnes Sze Yin Chan, Oi Man Yeung, Apple Chung Man Yuen, Connie Lai Yuk Chan, Paul Kay Sheung Tam, Wing Hung Leung, Ting Fan Early-Life Skin Microbial Biomarkers for Eczema Phenotypes in Chinese Toddlers |
title | Early-Life Skin Microbial Biomarkers for Eczema Phenotypes in Chinese Toddlers |
title_full | Early-Life Skin Microbial Biomarkers for Eczema Phenotypes in Chinese Toddlers |
title_fullStr | Early-Life Skin Microbial Biomarkers for Eczema Phenotypes in Chinese Toddlers |
title_full_unstemmed | Early-Life Skin Microbial Biomarkers for Eczema Phenotypes in Chinese Toddlers |
title_short | Early-Life Skin Microbial Biomarkers for Eczema Phenotypes in Chinese Toddlers |
title_sort | early-life skin microbial biomarkers for eczema phenotypes in chinese toddlers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222142/ https://www.ncbi.nlm.nih.gov/pubmed/37242367 http://dx.doi.org/10.3390/pathogens12050697 |
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