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The Effect of Intracellular Tacrolimus Exposure on Calcineurin Inhibition in Immediate- and Extended-Release Tacrolimus Formulations

Despite intensive monitoring of whole blood tacrolimus concentrations, acute rejection after kidney transplantation occurs during tacrolimus therapy. Intracellular tacrolimus concentrations could better reflect exposure at the site of action and its pharmacodynamics (PD). Intracellular pharmacokinet...

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Detalles Bibliográficos
Autores principales:	Fontova, Pere, van Merendonk, Lisanne N., Vidal-Alabró, Anna, Rigo-Bonnin, Raül, Cerezo, Gema, van Oevelen, Stefaan, Bestard, Oriol, Melilli, Edoardo, Montero, Nuria, Coloma, Ana, Manonelles, Anna, Torras, Joan, Cruzado, Josep M., Grinyó, Josep M., Colom, Helena, Lloberas, Nuria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222168/ https://www.ncbi.nlm.nih.gov/pubmed/37242723 http://dx.doi.org/10.3390/pharmaceutics15051481

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