Design, Synthesis, and Evaluation of Niclosamide Analogs as Therapeutic Agents for Enzalutamide-Resistant Prostate Cancer

Niclosamide effectively downregulates androgen receptor variants (AR-Vs) for treating enzalutamide and abiraterone-resistant prostate cancer. However, the poor pharmaceutical properties of niclosamide due to its solubility and metabolic instability have limited its clinical utility as a systemic tre...

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Detalles Bibliográficos
Autores principales: Kang, Borui, Mottamal, Madhusoodanan, Zhong, Qiu, Bratton, Melyssa, Zhang, Changde, Guo, Shanchun, Hossain, Ahamed, Ma, Peng, Zhang, Qiang, Wang, Guangdi, Payton-Stewart, Florastina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222209/
https://www.ncbi.nlm.nih.gov/pubmed/37242518
http://dx.doi.org/10.3390/ph16050735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222209/
https://www.ncbi.nlm.nih.gov/pubmed/37242518
http://dx.doi.org/10.3390/ph16050735

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