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COVID-19 Biomarkers Comparison: Children, Adults and Elders

Background and Objectives: this study aimed to research links between C-reactive protein (CRP), lactate dehydrogenase (LDH), creatinekinase (CK), 25-OH vitamin D (25-OHD), ferritin (FER), high-density lipoprotein cholesterol (HDL)cholesterol and clinical severity in patients from the western part of...

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Autores principales: Capraru, Ionut Dragos, Vulcanescu, Dan Dumitru, Bagiu, Iulia Cristina, Horhat, Florin George, Popescu, Irina Maria, Baditoiu, Luminita Mirela, Muntean, Delia, Licker, Monica, Radulescu, Matilda, Mot, Ion Cristian, Diaconu, Mircea Mihai, Marian, Catalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222231/
https://www.ncbi.nlm.nih.gov/pubmed/37241109
http://dx.doi.org/10.3390/medicina59050877
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author Capraru, Ionut Dragos
Vulcanescu, Dan Dumitru
Bagiu, Iulia Cristina
Horhat, Florin George
Popescu, Irina Maria
Baditoiu, Luminita Mirela
Muntean, Delia
Licker, Monica
Radulescu, Matilda
Mot, Ion Cristian
Diaconu, Mircea Mihai
Marian, Catalin
author_facet Capraru, Ionut Dragos
Vulcanescu, Dan Dumitru
Bagiu, Iulia Cristina
Horhat, Florin George
Popescu, Irina Maria
Baditoiu, Luminita Mirela
Muntean, Delia
Licker, Monica
Radulescu, Matilda
Mot, Ion Cristian
Diaconu, Mircea Mihai
Marian, Catalin
author_sort Capraru, Ionut Dragos
collection PubMed
description Background and Objectives: this study aimed to research links between C-reactive protein (CRP), lactate dehydrogenase (LDH), creatinekinase (CK), 25-OH vitamin D (25-OHD), ferritin (FER), high-density lipoprotein cholesterol (HDL)cholesterol and clinical severity in patients from the western part of Romania, and compare their potential use as biomarkers for intensive care units (ICU) admission and death in children, adults and elders. Materials and Methods: this study is a retrospective cohort study, performed on patients positively diagnosed with COVID-19. Available CRP, LDH, CK 25-OH vitamin D, ferritin, HDL cholesterol and clinical severity were recorded. The following were assessed: median group differences, association, correlation and receiver operating characteristic. Results: 381 children, 614 adults and 381 elders were studied between 1 March 2021 and 1 March 2022. Most children and adults presented mild symptomatology (53.28%, 35.02%, respectively), while most elders presented severe symptomatology (30.04%). ICU admission was 3.67% for children, 13.19% for adults and 46.09% for elders, while mortality was 0.79% for children, 8.63% for adults and 25.1% for elders. With the exception of CK, all other biomarkers showed some significant associations with clinical severity, ICU admission and death. Conclusions: CRP, LDH, 25-OH vitamin D, ferritin and HDL are important biomarkers for COVID-19 positive patients, especially in the pediatric population, while CK was mostly within normal ranges.
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spelling pubmed-102222312023-05-28 COVID-19 Biomarkers Comparison: Children, Adults and Elders Capraru, Ionut Dragos Vulcanescu, Dan Dumitru Bagiu, Iulia Cristina Horhat, Florin George Popescu, Irina Maria Baditoiu, Luminita Mirela Muntean, Delia Licker, Monica Radulescu, Matilda Mot, Ion Cristian Diaconu, Mircea Mihai Marian, Catalin Medicina (Kaunas) Article Background and Objectives: this study aimed to research links between C-reactive protein (CRP), lactate dehydrogenase (LDH), creatinekinase (CK), 25-OH vitamin D (25-OHD), ferritin (FER), high-density lipoprotein cholesterol (HDL)cholesterol and clinical severity in patients from the western part of Romania, and compare their potential use as biomarkers for intensive care units (ICU) admission and death in children, adults and elders. Materials and Methods: this study is a retrospective cohort study, performed on patients positively diagnosed with COVID-19. Available CRP, LDH, CK 25-OH vitamin D, ferritin, HDL cholesterol and clinical severity were recorded. The following were assessed: median group differences, association, correlation and receiver operating characteristic. Results: 381 children, 614 adults and 381 elders were studied between 1 March 2021 and 1 March 2022. Most children and adults presented mild symptomatology (53.28%, 35.02%, respectively), while most elders presented severe symptomatology (30.04%). ICU admission was 3.67% for children, 13.19% for adults and 46.09% for elders, while mortality was 0.79% for children, 8.63% for adults and 25.1% for elders. With the exception of CK, all other biomarkers showed some significant associations with clinical severity, ICU admission and death. Conclusions: CRP, LDH, 25-OH vitamin D, ferritin and HDL are important biomarkers for COVID-19 positive patients, especially in the pediatric population, while CK was mostly within normal ranges. MDPI 2023-05-03 /pmc/articles/PMC10222231/ /pubmed/37241109 http://dx.doi.org/10.3390/medicina59050877 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Capraru, Ionut Dragos
Vulcanescu, Dan Dumitru
Bagiu, Iulia Cristina
Horhat, Florin George
Popescu, Irina Maria
Baditoiu, Luminita Mirela
Muntean, Delia
Licker, Monica
Radulescu, Matilda
Mot, Ion Cristian
Diaconu, Mircea Mihai
Marian, Catalin
COVID-19 Biomarkers Comparison: Children, Adults and Elders
title COVID-19 Biomarkers Comparison: Children, Adults and Elders
title_full COVID-19 Biomarkers Comparison: Children, Adults and Elders
title_fullStr COVID-19 Biomarkers Comparison: Children, Adults and Elders
title_full_unstemmed COVID-19 Biomarkers Comparison: Children, Adults and Elders
title_short COVID-19 Biomarkers Comparison: Children, Adults and Elders
title_sort covid-19 biomarkers comparison: children, adults and elders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222231/
https://www.ncbi.nlm.nih.gov/pubmed/37241109
http://dx.doi.org/10.3390/medicina59050877
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