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COVID-19 Biomarkers Comparison: Children, Adults and Elders
Background and Objectives: this study aimed to research links between C-reactive protein (CRP), lactate dehydrogenase (LDH), creatinekinase (CK), 25-OH vitamin D (25-OHD), ferritin (FER), high-density lipoprotein cholesterol (HDL)cholesterol and clinical severity in patients from the western part of...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222231/ https://www.ncbi.nlm.nih.gov/pubmed/37241109 http://dx.doi.org/10.3390/medicina59050877 |
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author | Capraru, Ionut Dragos Vulcanescu, Dan Dumitru Bagiu, Iulia Cristina Horhat, Florin George Popescu, Irina Maria Baditoiu, Luminita Mirela Muntean, Delia Licker, Monica Radulescu, Matilda Mot, Ion Cristian Diaconu, Mircea Mihai Marian, Catalin |
author_facet | Capraru, Ionut Dragos Vulcanescu, Dan Dumitru Bagiu, Iulia Cristina Horhat, Florin George Popescu, Irina Maria Baditoiu, Luminita Mirela Muntean, Delia Licker, Monica Radulescu, Matilda Mot, Ion Cristian Diaconu, Mircea Mihai Marian, Catalin |
author_sort | Capraru, Ionut Dragos |
collection | PubMed |
description | Background and Objectives: this study aimed to research links between C-reactive protein (CRP), lactate dehydrogenase (LDH), creatinekinase (CK), 25-OH vitamin D (25-OHD), ferritin (FER), high-density lipoprotein cholesterol (HDL)cholesterol and clinical severity in patients from the western part of Romania, and compare their potential use as biomarkers for intensive care units (ICU) admission and death in children, adults and elders. Materials and Methods: this study is a retrospective cohort study, performed on patients positively diagnosed with COVID-19. Available CRP, LDH, CK 25-OH vitamin D, ferritin, HDL cholesterol and clinical severity were recorded. The following were assessed: median group differences, association, correlation and receiver operating characteristic. Results: 381 children, 614 adults and 381 elders were studied between 1 March 2021 and 1 March 2022. Most children and adults presented mild symptomatology (53.28%, 35.02%, respectively), while most elders presented severe symptomatology (30.04%). ICU admission was 3.67% for children, 13.19% for adults and 46.09% for elders, while mortality was 0.79% for children, 8.63% for adults and 25.1% for elders. With the exception of CK, all other biomarkers showed some significant associations with clinical severity, ICU admission and death. Conclusions: CRP, LDH, 25-OH vitamin D, ferritin and HDL are important biomarkers for COVID-19 positive patients, especially in the pediatric population, while CK was mostly within normal ranges. |
format | Online Article Text |
id | pubmed-10222231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102222312023-05-28 COVID-19 Biomarkers Comparison: Children, Adults and Elders Capraru, Ionut Dragos Vulcanescu, Dan Dumitru Bagiu, Iulia Cristina Horhat, Florin George Popescu, Irina Maria Baditoiu, Luminita Mirela Muntean, Delia Licker, Monica Radulescu, Matilda Mot, Ion Cristian Diaconu, Mircea Mihai Marian, Catalin Medicina (Kaunas) Article Background and Objectives: this study aimed to research links between C-reactive protein (CRP), lactate dehydrogenase (LDH), creatinekinase (CK), 25-OH vitamin D (25-OHD), ferritin (FER), high-density lipoprotein cholesterol (HDL)cholesterol and clinical severity in patients from the western part of Romania, and compare their potential use as biomarkers for intensive care units (ICU) admission and death in children, adults and elders. Materials and Methods: this study is a retrospective cohort study, performed on patients positively diagnosed with COVID-19. Available CRP, LDH, CK 25-OH vitamin D, ferritin, HDL cholesterol and clinical severity were recorded. The following were assessed: median group differences, association, correlation and receiver operating characteristic. Results: 381 children, 614 adults and 381 elders were studied between 1 March 2021 and 1 March 2022. Most children and adults presented mild symptomatology (53.28%, 35.02%, respectively), while most elders presented severe symptomatology (30.04%). ICU admission was 3.67% for children, 13.19% for adults and 46.09% for elders, while mortality was 0.79% for children, 8.63% for adults and 25.1% for elders. With the exception of CK, all other biomarkers showed some significant associations with clinical severity, ICU admission and death. Conclusions: CRP, LDH, 25-OH vitamin D, ferritin and HDL are important biomarkers for COVID-19 positive patients, especially in the pediatric population, while CK was mostly within normal ranges. MDPI 2023-05-03 /pmc/articles/PMC10222231/ /pubmed/37241109 http://dx.doi.org/10.3390/medicina59050877 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Capraru, Ionut Dragos Vulcanescu, Dan Dumitru Bagiu, Iulia Cristina Horhat, Florin George Popescu, Irina Maria Baditoiu, Luminita Mirela Muntean, Delia Licker, Monica Radulescu, Matilda Mot, Ion Cristian Diaconu, Mircea Mihai Marian, Catalin COVID-19 Biomarkers Comparison: Children, Adults and Elders |
title | COVID-19 Biomarkers Comparison: Children, Adults and Elders |
title_full | COVID-19 Biomarkers Comparison: Children, Adults and Elders |
title_fullStr | COVID-19 Biomarkers Comparison: Children, Adults and Elders |
title_full_unstemmed | COVID-19 Biomarkers Comparison: Children, Adults and Elders |
title_short | COVID-19 Biomarkers Comparison: Children, Adults and Elders |
title_sort | covid-19 biomarkers comparison: children, adults and elders |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222231/ https://www.ncbi.nlm.nih.gov/pubmed/37241109 http://dx.doi.org/10.3390/medicina59050877 |
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