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Discrepancies in Embryonic Staging: Towards a Gold Standard

For over half a century, the Carnegie staging system has been used for the unification of chronology in human embryo development. Despite the system’s establishment as a “universal” system, Carnegie staging reference charts display a high level of variation. To establish a clear understanding for em...

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Autores principales: Flierman, Sander, Tijsterman, Melanie, Rousian, Melek, de Bakker, Bernadette S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222295/
https://www.ncbi.nlm.nih.gov/pubmed/37240729
http://dx.doi.org/10.3390/life13051084
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author Flierman, Sander
Tijsterman, Melanie
Rousian, Melek
de Bakker, Bernadette S.
author_facet Flierman, Sander
Tijsterman, Melanie
Rousian, Melek
de Bakker, Bernadette S.
author_sort Flierman, Sander
collection PubMed
description For over half a century, the Carnegie staging system has been used for the unification of chronology in human embryo development. Despite the system’s establishment as a “universal” system, Carnegie staging reference charts display a high level of variation. To establish a clear understanding for embryologists and medical professionals, we aimed to answer the following question: does a gold standard of Carnegie staging exist, and if so, which set of proposed measures/characteristics would it include? We aimed to provide a clear overview of the variations in published Carnegie staging charts to compare and analyze these differences and propose potential explanatory factors. A review of the literature was performed, wherein 113 publications were identified and screened based on title and abstract. Twenty-six relevant titles and abstracts were assessed based on the full text. After exclusion, nine remaining publications were critically appraised. We observed consistent variations in data sets, especially regarding embryonic age, varying as large as 11 days between publications. Similarly, for embryonic length, large variations were present. These large variations are possibly attributable to sampling differences, developing technology, and differences in data collection. Based on the reviewed studies, we propose the Carnegie staging system of Prof. Hill as a gold standard amongst the available data sets in the literature.
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spelling pubmed-102222952023-05-28 Discrepancies in Embryonic Staging: Towards a Gold Standard Flierman, Sander Tijsterman, Melanie Rousian, Melek de Bakker, Bernadette S. Life (Basel) Review For over half a century, the Carnegie staging system has been used for the unification of chronology in human embryo development. Despite the system’s establishment as a “universal” system, Carnegie staging reference charts display a high level of variation. To establish a clear understanding for embryologists and medical professionals, we aimed to answer the following question: does a gold standard of Carnegie staging exist, and if so, which set of proposed measures/characteristics would it include? We aimed to provide a clear overview of the variations in published Carnegie staging charts to compare and analyze these differences and propose potential explanatory factors. A review of the literature was performed, wherein 113 publications were identified and screened based on title and abstract. Twenty-six relevant titles and abstracts were assessed based on the full text. After exclusion, nine remaining publications were critically appraised. We observed consistent variations in data sets, especially regarding embryonic age, varying as large as 11 days between publications. Similarly, for embryonic length, large variations were present. These large variations are possibly attributable to sampling differences, developing technology, and differences in data collection. Based on the reviewed studies, we propose the Carnegie staging system of Prof. Hill as a gold standard amongst the available data sets in the literature. MDPI 2023-04-26 /pmc/articles/PMC10222295/ /pubmed/37240729 http://dx.doi.org/10.3390/life13051084 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Flierman, Sander
Tijsterman, Melanie
Rousian, Melek
de Bakker, Bernadette S.
Discrepancies in Embryonic Staging: Towards a Gold Standard
title Discrepancies in Embryonic Staging: Towards a Gold Standard
title_full Discrepancies in Embryonic Staging: Towards a Gold Standard
title_fullStr Discrepancies in Embryonic Staging: Towards a Gold Standard
title_full_unstemmed Discrepancies in Embryonic Staging: Towards a Gold Standard
title_short Discrepancies in Embryonic Staging: Towards a Gold Standard
title_sort discrepancies in embryonic staging: towards a gold standard
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222295/
https://www.ncbi.nlm.nih.gov/pubmed/37240729
http://dx.doi.org/10.3390/life13051084
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