Cargando…

Assessing the Operational Feasibility of Integrating Point-of-Care G6PD Testing into Plasmodium vivax Malaria Management in Vietnam

Plasmodium vivax cases represent more than 50% of a diminishing malaria case load in Vietnam. Safe and effective radical cure strategies could support malaria elimination by 2030. This study investigated the operational feasibility of introducing point-of-care quantitative glucose-6-phosphate dehydr...

Descripción completa

Detalles Bibliográficos
Autores principales: Gerth-Guyette, Emily, Nguyen, Huyen Thanh, Nowak, Spike, Hoang, Nga Thu, Mai, Đặng Thị Tuyết, Thị Sang, Vũ, Long, Nguyễn Đức, Mvundura, Mercy, Nguyen, Nhu, Domingo, Gonzalo J., Phúc, Bùi Quang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222310/
https://www.ncbi.nlm.nih.gov/pubmed/37242359
http://dx.doi.org/10.3390/pathogens12050689
_version_ 1785049667251208192
author Gerth-Guyette, Emily
Nguyen, Huyen Thanh
Nowak, Spike
Hoang, Nga Thu
Mai, Đặng Thị Tuyết
Thị Sang, Vũ
Long, Nguyễn Đức
Mvundura, Mercy
Nguyen, Nhu
Domingo, Gonzalo J.
Phúc, Bùi Quang
author_facet Gerth-Guyette, Emily
Nguyen, Huyen Thanh
Nowak, Spike
Hoang, Nga Thu
Mai, Đặng Thị Tuyết
Thị Sang, Vũ
Long, Nguyễn Đức
Mvundura, Mercy
Nguyen, Nhu
Domingo, Gonzalo J.
Phúc, Bùi Quang
author_sort Gerth-Guyette, Emily
collection PubMed
description Plasmodium vivax cases represent more than 50% of a diminishing malaria case load in Vietnam. Safe and effective radical cure strategies could support malaria elimination by 2030. This study investigated the operational feasibility of introducing point-of-care quantitative glucose-6-phosphate dehydrogenase (G6PD) testing into malaria case management practices. A prospective interventional study was conducted at nine district hospitals and commune health stations in Binh Phuoc and Gia Lai provinces in Vietnam over the period of October 2020 to October 2021. The STANDARD™ G6PD Test (SD Biosensor, Seoul, Republic of Korea) was incorporated to inform P. vivax case management. Case management data and patient and health care provider (HCP) perspectives, as well as detailed cost data were collected. The G6PD test results were interpreted correctly by HCP and the treatment algorithm was adhered to for the majority of patients. One HCP consistently ran the test incorrectly, which was identified during the monitoring and resulted in provision of refresher training and updating of training materials and patient retesting. There was wide acceptability of the intervention among patients and HCP albeit with opportunities to improve the counseling materials. Increasing the number of facilities to which the test was deployed and decreases in the malaria cases resulted in higher per patient cost for incorporating G6PD testing into the system. Commodity costs can be reduced by using the 10-unit kits compared to the 25 unit kits, particularly when the case loads are low. These results demonstrate intervention feasibility while also highlighting specific challenges for a country approaching malaria elimination.
format Online
Article
Text
id pubmed-10222310
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102223102023-05-28 Assessing the Operational Feasibility of Integrating Point-of-Care G6PD Testing into Plasmodium vivax Malaria Management in Vietnam Gerth-Guyette, Emily Nguyen, Huyen Thanh Nowak, Spike Hoang, Nga Thu Mai, Đặng Thị Tuyết Thị Sang, Vũ Long, Nguyễn Đức Mvundura, Mercy Nguyen, Nhu Domingo, Gonzalo J. Phúc, Bùi Quang Pathogens Article Plasmodium vivax cases represent more than 50% of a diminishing malaria case load in Vietnam. Safe and effective radical cure strategies could support malaria elimination by 2030. This study investigated the operational feasibility of introducing point-of-care quantitative glucose-6-phosphate dehydrogenase (G6PD) testing into malaria case management practices. A prospective interventional study was conducted at nine district hospitals and commune health stations in Binh Phuoc and Gia Lai provinces in Vietnam over the period of October 2020 to October 2021. The STANDARD™ G6PD Test (SD Biosensor, Seoul, Republic of Korea) was incorporated to inform P. vivax case management. Case management data and patient and health care provider (HCP) perspectives, as well as detailed cost data were collected. The G6PD test results were interpreted correctly by HCP and the treatment algorithm was adhered to for the majority of patients. One HCP consistently ran the test incorrectly, which was identified during the monitoring and resulted in provision of refresher training and updating of training materials and patient retesting. There was wide acceptability of the intervention among patients and HCP albeit with opportunities to improve the counseling materials. Increasing the number of facilities to which the test was deployed and decreases in the malaria cases resulted in higher per patient cost for incorporating G6PD testing into the system. Commodity costs can be reduced by using the 10-unit kits compared to the 25 unit kits, particularly when the case loads are low. These results demonstrate intervention feasibility while also highlighting specific challenges for a country approaching malaria elimination. MDPI 2023-05-08 /pmc/articles/PMC10222310/ /pubmed/37242359 http://dx.doi.org/10.3390/pathogens12050689 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gerth-Guyette, Emily
Nguyen, Huyen Thanh
Nowak, Spike
Hoang, Nga Thu
Mai, Đặng Thị Tuyết
Thị Sang, Vũ
Long, Nguyễn Đức
Mvundura, Mercy
Nguyen, Nhu
Domingo, Gonzalo J.
Phúc, Bùi Quang
Assessing the Operational Feasibility of Integrating Point-of-Care G6PD Testing into Plasmodium vivax Malaria Management in Vietnam
title Assessing the Operational Feasibility of Integrating Point-of-Care G6PD Testing into Plasmodium vivax Malaria Management in Vietnam
title_full Assessing the Operational Feasibility of Integrating Point-of-Care G6PD Testing into Plasmodium vivax Malaria Management in Vietnam
title_fullStr Assessing the Operational Feasibility of Integrating Point-of-Care G6PD Testing into Plasmodium vivax Malaria Management in Vietnam
title_full_unstemmed Assessing the Operational Feasibility of Integrating Point-of-Care G6PD Testing into Plasmodium vivax Malaria Management in Vietnam
title_short Assessing the Operational Feasibility of Integrating Point-of-Care G6PD Testing into Plasmodium vivax Malaria Management in Vietnam
title_sort assessing the operational feasibility of integrating point-of-care g6pd testing into plasmodium vivax malaria management in vietnam
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222310/
https://www.ncbi.nlm.nih.gov/pubmed/37242359
http://dx.doi.org/10.3390/pathogens12050689
work_keys_str_mv AT gerthguyetteemily assessingtheoperationalfeasibilityofintegratingpointofcareg6pdtestingintoplasmodiumvivaxmalariamanagementinvietnam
AT nguyenhuyenthanh assessingtheoperationalfeasibilityofintegratingpointofcareg6pdtestingintoplasmodiumvivaxmalariamanagementinvietnam
AT nowakspike assessingtheoperationalfeasibilityofintegratingpointofcareg6pdtestingintoplasmodiumvivaxmalariamanagementinvietnam
AT hoangngathu assessingtheoperationalfeasibilityofintegratingpointofcareg6pdtestingintoplasmodiumvivaxmalariamanagementinvietnam
AT maiđangthituyet assessingtheoperationalfeasibilityofintegratingpointofcareg6pdtestingintoplasmodiumvivaxmalariamanagementinvietnam
AT thisangvu assessingtheoperationalfeasibilityofintegratingpointofcareg6pdtestingintoplasmodiumvivaxmalariamanagementinvietnam
AT longnguyenđuc assessingtheoperationalfeasibilityofintegratingpointofcareg6pdtestingintoplasmodiumvivaxmalariamanagementinvietnam
AT mvunduramercy assessingtheoperationalfeasibilityofintegratingpointofcareg6pdtestingintoplasmodiumvivaxmalariamanagementinvietnam
AT nguyennhu assessingtheoperationalfeasibilityofintegratingpointofcareg6pdtestingintoplasmodiumvivaxmalariamanagementinvietnam
AT domingogonzaloj assessingtheoperationalfeasibilityofintegratingpointofcareg6pdtestingintoplasmodiumvivaxmalariamanagementinvietnam
AT phucbuiquang assessingtheoperationalfeasibilityofintegratingpointofcareg6pdtestingintoplasmodiumvivaxmalariamanagementinvietnam